Gonadal Function and Fertility after Hodgkin Lymphoma Treatment with Nivolumab-AVD in the Phase II GHSG NIVAHL Trial.

Robertz AS; Bühnen I; Meissner J; Trautmann-Grill K; Herhaus P; Halbsguth T; Schaub V; Kerkhoff A; Mathas S; Bormann M; Dickhut A; Jaworek CP; Fuchs M; Kobe C; Baues C; Borchmann P; von Tresckow B; Behringer K; Bröckelmann PJ

doi:10.1182/blood.2025031809

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Gonadal Function and Fertility after Hodgkin Lymphoma Treatment with Nivolumab-AVD in the Phase II GHSG NIVAHL Trial.

Blood 2026

Robertz AS, Bühnen I, Meissner J, Trautmann-Grill K, Herhaus P, Halbsguth T, Schaub V, Kerkhoff A, Mathas S, Bormann M, Dickhut A, Jaworek CP, Fuchs M, Kobe C, Baues C, Borchmann P, von Tresckow B, Behringer K, Bröckelmann PJ

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In 82 patients with classic Hodgkin lymphoma, stable gonadal hormone levels were observed up to 24 months after nivolumab and AVD (N-AVD) first-line treatment in the NIVAHL trial.

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APA Robertz AS, Bühnen I, et al. (2026). Gonadal Function and Fertility after Hodgkin Lymphoma Treatment with Nivolumab-AVD in the Phase II GHSG NIVAHL Trial.. Blood. https://doi.org/10.1182/blood.2025031809

MLA Robertz AS, et al.. "Gonadal Function and Fertility after Hodgkin Lymphoma Treatment with Nivolumab-AVD in the Phase II GHSG NIVAHL Trial.." Blood, 2026.

PMID 41926569

DOI 10.1182/blood.2025031809

Abstract

In 82 patients with classic Hodgkin lymphoma, stable gonadal hormone levels were observed up to 24 months after nivolumab and AVD (N-AVD) first-line treatment in the NIVAHL trial. These findings suggest preserved gonadal function and fertility following 4×N-AVD. NCT03004833.