Reciprocal Clonal Dynamics of Independent D835V-Positive Acute Myeloid Leukemia and Chronic Myeloid Leukemia With Gilteritinib.
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OpenAlex 토픽 ·
Acute Myeloid Leukemia Research
Chronic Myeloid Leukemia Treatments
Myeloproliferative Neoplasms: Diagnosis and Treatment
We report a 65-year-old man with D835V-mutated acute myeloid leukemia (AML) and -positive chronic myeloid leukemia (CML) that coexisted as genetically independent clones.
APA
Kai Osone, Seiichiro Katagiri, et al. (2026). Reciprocal Clonal Dynamics of Independent D835V-Positive Acute Myeloid Leukemia and Chronic Myeloid Leukemia With Gilteritinib.. EJHaem, 7, e70289. https://doi.org/10.1002/jha2.70289
MLA
Kai Osone, et al.. "Reciprocal Clonal Dynamics of Independent D835V-Positive Acute Myeloid Leukemia and Chronic Myeloid Leukemia With Gilteritinib.." EJHaem, vol. 7, 2026, pp. e70289.
PMID
41982787 ↗
Abstract 한글 요약
We report a 65-year-old man with D835V-mutated acute myeloid leukemia (AML) and -positive chronic myeloid leukemia (CML) that coexisted as genetically independent clones. Cytogenetic and targeted sequencing analyses demonstrated that the AML and CML clones coexisted as distinct entities. During treatment with gilteritinib, the AML blasts regressed, and then the CML clone expanded. Subsequently, the CML burden declined as the AML clone regrew. This case highlights the importance of accurately assessing clonal changes using genetic analysis when implementing molecular targeted therapy for hematologic malignancies.
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