Outstanding Questions to Understand and Target Splicing Factor-Mutant Blood Cancers.
OpenAlex 토픽 ·
RNA Research and Splicing
Acute Myeloid Leukemia Research
Nuclear Structure and Function
Mutations in genes encoding RNA splicing factors are common in patients with myeloid malignancies and chronic lymphocytic leukemia.
APA
Maxim I. Maron, Omar Abdel‐Wahab (2026). Outstanding Questions to Understand and Target Splicing Factor-Mutant Blood Cancers.. Blood cancer discovery, OF1-OF5. https://doi.org/10.1158/2643-3230.BCD-26-0047
MLA
Maxim I. Maron, et al.. "Outstanding Questions to Understand and Target Splicing Factor-Mutant Blood Cancers.." Blood cancer discovery, 2026, pp. OF1-OF5.
PMID
42013378
Abstract
Mutations in genes encoding RNA splicing factors are common in patients with myeloid malignancies and chronic lymphocytic leukemia. In this commentary, we discuss key unanswered questions on the causal role of these mutations in blood cancers and precursor conditions as well as efforts to develop therapies targeting these high-frequency neomorphic mutations.