Dysregulated endometrial podocalyxin and LIF expression in women with ovarian endometrioma.
단면연구
2/5 보강
OpenAlex 토픽 ·
Endometriosis Research and Treatment
Uterine Myomas and Treatments
Coagulation, Bradykinin, Polyphosphates, and Angioedema
[OBJECTIVE] To investigate whether ovarian endometrioma is associated with disruption of the endocrine-regulated transition between the anti-adhesive modulator podocalyxin (PCX) and the adhesive modul
- p-value p < 0.001
- 연구 설계 cross-sectional
APA
Gökçenur Karakelleoğlu, Cihan Karadağ (2026). Dysregulated endometrial podocalyxin and LIF expression in women with ovarian endometrioma.. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 42(1), 2662696. https://doi.org/10.1080/09513590.2026.2662696
MLA
Gökçenur Karakelleoğlu, et al.. "Dysregulated endometrial podocalyxin and LIF expression in women with ovarian endometrioma.." Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, vol. 42, no. 1, 2026, pp. 2662696.
PMID
42015488 ↗
Abstract 한글 요약
[OBJECTIVE] To investigate whether ovarian endometrioma is associated with disruption of the endocrine-regulated transition between the anti-adhesive modulator podocalyxin (PCX) and the adhesive modulator leukemia inhibitory factor (LIF) in the endometrium.
[METHODS] This cross-sectional study included 42 women (32 infertile, 10 fertile controls). Among infertile participants, 17 had ovarian endometrioma (EOC), seven had non-endometriotic cysts, and eight had prior infertility treatment failure. Endometrial tissue obtained via laparoscopy or hysteroscopy was analyzed in 30 women with mid- or late-luteal endometrium. PCX mRNA, PCX protein, and LIF mRNA levels were assessed using qRT-PCR and ELISA.
[RESULTS] LIF mRNA expression was significantly lower in the EOC group compared to all other groups (p < 0.001), while PCX mRNA and protein levels were higher (p < 0.001). Progesterone levels negatively correlated with PCX mRNA (r = -0.48, = 0.007) and protein (r = -0.45, = 0.012). LIF expression showed strong negative correlations with PCX mRNA (r = -0.81) and protein (r = -0.82) (p < 0.001). No associations were found with cyst characteristics.
[CONCLUSION] Ovarian endometrioma is associated with disruption of the PCX-LIF transition, suggesting impaired endometrial progesterone responsiveness.
[METHODS] This cross-sectional study included 42 women (32 infertile, 10 fertile controls). Among infertile participants, 17 had ovarian endometrioma (EOC), seven had non-endometriotic cysts, and eight had prior infertility treatment failure. Endometrial tissue obtained via laparoscopy or hysteroscopy was analyzed in 30 women with mid- or late-luteal endometrium. PCX mRNA, PCX protein, and LIF mRNA levels were assessed using qRT-PCR and ELISA.
[RESULTS] LIF mRNA expression was significantly lower in the EOC group compared to all other groups (p < 0.001), while PCX mRNA and protein levels were higher (p < 0.001). Progesterone levels negatively correlated with PCX mRNA (r = -0.48, = 0.007) and protein (r = -0.45, = 0.012). LIF expression showed strong negative correlations with PCX mRNA (r = -0.81) and protein (r = -0.82) (p < 0.001). No associations were found with cyst characteristics.
[CONCLUSION] Ovarian endometrioma is associated with disruption of the PCX-LIF transition, suggesting impaired endometrial progesterone responsiveness.
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