Effect of Sodium-Glucose Co-Transporter 2 Inhibitors Combined with Metformin on Pancreatic Cancer Cell Lines.
1/5 보강
Pancreatic cancer (PC) is the ninth-leading cause of cancer-related deaths worldwide.
APA
Cristovão A, Andrade N, et al. (2024). Effect of Sodium-Glucose Co-Transporter 2 Inhibitors Combined with Metformin on Pancreatic Cancer Cell Lines.. International journal of molecular sciences, 25(18). https://doi.org/10.3390/ijms25189932
MLA
Cristovão A, et al.. "Effect of Sodium-Glucose Co-Transporter 2 Inhibitors Combined with Metformin on Pancreatic Cancer Cell Lines.." International journal of molecular sciences, vol. 25, no. 18, 2024.
PMID
39337420 ↗
Abstract 한글 요약
Pancreatic cancer (PC) is the ninth-leading cause of cancer-related deaths worldwide. Diabetic patients have an increased risk and mortality rates for PC. Sodium-glucose co-transporter 2 (SGLT2) inhibitors and metformin (Met) are widely used anti-diabetic medications. Both Met and SGLT2 inhibitors have anticancer properties in PC, but nothing is known concerning their combined effect. So, we investigated the in vitro effect of SGLT2 inhibitors combined with Met. Canagliflozin and dapagliflozin possessed cytotoxic, antiproliferative, and pro-apoptotic properties in the tested PC cell lines. In PANC-1 cells, the antimigratory and pro-apoptotic effects were enhanced when dapagliflozin was combined with Met, and G1 cell cycle arrest was enhanced when dapagliflozin or canagliflozin was combined with Met. In AsPC-1 cells, the cytotoxic effect and the G1 cell cycle arrest were enhanced when canagliflozin and dapagliflozin, respectively, were combined with Met. Only the cytotoxic effects of SGLT2 inhibitors, but not the combination treatments, involved PI3K and JNK-dependent pathways in AsPC-1 cells. In conclusion, combination treatments increased the anticancer effects in a cell type-dependent way in the two investigated cell lines. Additionally, the cytotoxic effect of SGLT2 inhibitors was dependent on the PI3K and JNK pathways in AsPC-1 cells, but Met appears to act via a distinct mechanism.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Metformin
- Humans
- Sodium-Glucose Transporter 2 Inhibitors
- Pancreatic Neoplasms
- Cell Line
- Tumor
- Canagliflozin
- Cell Proliferation
- Benzhydryl Compounds
- Apoptosis
- Glucosides
- Hypoglycemic Agents
- Sodium-Glucose Transporter 2
- Cell Movement
- Drug Synergism
- PI3K and JNK intracellular signaling pathways
- Panc-1 and AsPC-1 pancreatic cancer cell lines
- SGLT2 inhibitors
- metformin
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