How to find a needle in a haystack: a systematic review on targeting KRAS wild-type pancreatic cancer.

Pancreatic adenocarcinoma is a very aggressive type of cancer, in which targeted therapies have not yet been fully utilized. wild-type pancreatic adenocarcinoma tumors are associated with different genomic alterations in comparison to mutated pancreatic adenocarcinoma. This systematic review aims to provide a one-stop summary of all these alterations, their proposed targeted treatment and their effect on disease progression. An electronic search strategy was elaborated in the PubMed database between 2020 and January 2024. 21 studies were included, and we found that the most frequent targetable genomic alterations in wild-type pancreatic adenocarcinoma were , , , , amplification, and other HRDs, and gene fusions like , and .