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Regorafenib induces DNA damage and enhances PARP inhibitor efficacy in pancreatic ductal carcinoma.

1/5 보강

BMC cancer 📖 저널 OA 96.4% 2021~2026 2024 Vol.24(1) p. 1562

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

환자: defects in DNA damage repair associated with germline BRCA1/2 mutations

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

Notably, we show that the efficacy of the combination treatment is not dependent on cytolytic T cells. [CONCLUSIONS] Together, these findings demonstrate that regorafenib can attenuate DNA damage response and potentiate the efficacy of PARP inhibitors in PDAC tumors.

Pham TD, Becker JH, Metropulos AE, Mubin N, Spaulding C, Bentrem DJ

📖 무료 전문 🟢 PMC 전문 PMC11662535

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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