Synthesis and physico-chemical investigation of thiolated dextran derivative: Design and application of a redox-responsive drug delivery system.
1/5 보강
In the present investigation, redox-responsive-based dextran carriers were developed for the controlled release of hydrophobic molecules via a reducing agent naturally present in cells, namely glutath
APA
Chesneau C, Pelletier A, et al. (2025). Synthesis and physico-chemical investigation of thiolated dextran derivative: Design and application of a redox-responsive drug delivery system.. International journal of biological macromolecules, 297, 139861. https://doi.org/10.1016/j.ijbiomac.2025.139861
MLA
Chesneau C, et al.. "Synthesis and physico-chemical investigation of thiolated dextran derivative: Design and application of a redox-responsive drug delivery system.." International journal of biological macromolecules, vol. 297, 2025, pp. 139861.
PMID
39814291 ↗
Abstract 한글 요약
In the present investigation, redox-responsive-based dextran carriers were developed for the controlled release of hydrophobic molecules via a reducing agent naturally present in cells, namely glutathione. In this sense, dextran was modified with a thiol derivative. The roles of the hydrophilic segments in the molecular self-organisation of polysaccharide derivatives into nanoparticles were investigated by varying the average dextran molar mass. Crosslinked thiolated dextran particles were good carriers of hydrophobic molecules such as Nile red dye, which were efficiently encapsulated in the hydrophobic core and then selectively released. Indeed, the disulfide linkage connecting the hydrophobic tail with dextran was found to be cleaved by glutathione under physiological conditions for the fast release of Nile red. The cytotoxicity of the dextran-based particles was examined, and it was found to be nontoxic to living cells. Finally, we explored the versatility of dextran-derived particle drug carriers for pancreatic cancer treatment. The designed carriers were loaded with the anticancer drug paclitaxel and the obtained particles exhibited redox-responsive drug release and excellent anticancer activities with up to 90 % inhibition of cancer cell viability. Thus, the developed dextran derivatives are highly promising and suitable for a wide range of biomedical applications that require the loading and release of hydrophobic compounds.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Dextrans
- Oxidation-Reduction
- Humans
- Drug Carriers
- Drug Liberation
- Sulfhydryl Compounds
- Drug Delivery Systems
- Hydrophobic and Hydrophilic Interactions
- Paclitaxel
- Cell Line
- Tumor
- Nanoparticles
- Cell Survival
- Antineoplastic Agents
- Hydrophobic loading
- Modification
- Particles
- Redox-responsive
- Thiolated dextran
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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