TRPS1 is a useful marker in differentiating metastatic breast carcinoma from pancreatic adenocarcinoma in fine-needle aspiration specimens.
1/5 보강
[OBJECTIVES] Distinction of metastatic breast carcinoma (BC) to the pancreas from primary pancreatic adenocarcinoma (PAC) is essential but challenging.
- 표본수 (n) 49
APA
Yildiz B, Jean-Gilles J, et al. (2025). TRPS1 is a useful marker in differentiating metastatic breast carcinoma from pancreatic adenocarcinoma in fine-needle aspiration specimens.. American journal of clinical pathology, 163(4), 581-585. https://doi.org/10.1093/ajcp/aqae155
MLA
Yildiz B, et al.. "TRPS1 is a useful marker in differentiating metastatic breast carcinoma from pancreatic adenocarcinoma in fine-needle aspiration specimens.." American journal of clinical pathology, vol. 163, no. 4, 2025, pp. 581-585.
PMID
39656998 ↗
Abstract 한글 요약
[OBJECTIVES] Distinction of metastatic breast carcinoma (BC) to the pancreas from primary pancreatic adenocarcinoma (PAC) is essential but challenging. Breast carcinoma shares similar morphology and exhibits an overlapping immunohistochemistry (IHC) profile with PAC. We investigated the utility of recently reported trichorhinophalangeal syndrome type 1 (TRPS1) IHC in differentiating metastatic BC from PAC in fine-needle aspiration (FNA) specimens.
[METHODS] We assessed consecutive patients of PAC (n = 49). Due to limited cases of metastatic BC to the pancreas (n = 3), cases of metastatic BC (n = 23) in various locations, including lymph node, lung, bone, or soft tissue, were included. Immunohistochemistry for TRPS1 was performed by using the cell blocks obtained from FNA. A quantitative score for TRPS1 expression was calculated by multiplying the intensity and the percentage of positive cells. Immunoreactivity scores were assigned as negative, low positive, intermediate positive, or high positive.
[RESULTS] In 49 PAC cases, 47 (95.9%) exhibited negative while 2 (4.1%) exhibited low positive TRPS1 expression. However, TRPS1 expression was high positive in 23 (88.0%) of 26 metastatic BC cases, including 10 (83.3%) of 12 triple-negative BC (TNBC) and 13 (92.9%) of 14 non-TNBC cases.
[CONCLUSIONS] Our results suggest that TRPS1 IHC represents a highly accurate and reliable method for differentiating metastatic BC from PAC.
[METHODS] We assessed consecutive patients of PAC (n = 49). Due to limited cases of metastatic BC to the pancreas (n = 3), cases of metastatic BC (n = 23) in various locations, including lymph node, lung, bone, or soft tissue, were included. Immunohistochemistry for TRPS1 was performed by using the cell blocks obtained from FNA. A quantitative score for TRPS1 expression was calculated by multiplying the intensity and the percentage of positive cells. Immunoreactivity scores were assigned as negative, low positive, intermediate positive, or high positive.
[RESULTS] In 49 PAC cases, 47 (95.9%) exhibited negative while 2 (4.1%) exhibited low positive TRPS1 expression. However, TRPS1 expression was high positive in 23 (88.0%) of 26 metastatic BC cases, including 10 (83.3%) of 12 triple-negative BC (TNBC) and 13 (92.9%) of 14 non-TNBC cases.
[CONCLUSIONS] Our results suggest that TRPS1 IHC represents a highly accurate and reliable method for differentiating metastatic BC from PAC.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Female
- Pancreatic Neoplasms
- Biomarkers
- Tumor
- Biopsy
- Fine-Needle
- Diagnosis
- Differential
- Breast Neoplasms
- DNA-Binding Proteins
- Adenocarcinoma
- Repressor Proteins
- Transcription Factors
- Middle Aged
- Aged
- Immunohistochemistry
- Adult
- 80 and over
- fine-needle aspiration
- metastatic breast carcinoma
- pancreatic adenocarcinoma
- trichorhinophalangeal syndrome type 1
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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