Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery.
[BACKGROUND] Patients with pancreatic cancer are at increased risk of malnutrition and functional decline.
APA
Lidoriki I, Frountzas M, et al. (2025). Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery.. Life (Basel, Switzerland), 15(5). https://doi.org/10.3390/life15050803
MLA
Lidoriki I, et al.. "Exploring the Link Between Nutritional and Functional Status and Short-Term Postoperative Outcomes in Patients Undergoing Pancreatic Cancer Surgery.." Life (Basel, Switzerland), vol. 15, no. 5, 2025.
PMID
40430229
Abstract
[BACKGROUND] Patients with pancreatic cancer are at increased risk of malnutrition and functional decline. This study aimed to identify preoperative nutritional and functional risk factors associated with postoperative complications.
[METHODS] Adult patients with pancreatic cancer admitted to two university surgical departments in Athens, Greece, were included. Preoperative laboratory values, nutritional status, and functional status were assessed.
[RESULTS] Among 96 patients included in this study, postoperative complications occurred in 69 (71.9%). Complication rates were significantly higher in patients with severe malnutrition (87.9% vs. 62.7%, = 0.015), low Geriatric Nutritional Risk Index (GNRI) (90.5% vs. 66.2%, = 0.023), low handgrip strength (91.7% vs. 61.5%, = 0.037), and low gait speed (90.5% vs. 63.6%, = 0.027). Major complications were linked to lower hemoglobin (Hb) (11.5 ± 1.9 vs. 12.8 ± 1.7 g/dL, = 0.001), lower hematocrit (HCT) (34.7 ± 5.4% vs. 38.4 ± 4.7%, = 0.001), and severe malnutrition (42.4% vs. 23.7%, = 0.05). Lower Hb, lower HCT, malnutrition, and greater waist circumference were associated with postoperative mortality. Longer hospital stays were correlated with weaker handgrip strength and slower gait speed.
[CONCLUSION] Preoperative malnutrition and impaired functional status are significant predictors of adverse postoperative outcomes in pancreatic cancer surgery.
[METHODS] Adult patients with pancreatic cancer admitted to two university surgical departments in Athens, Greece, were included. Preoperative laboratory values, nutritional status, and functional status were assessed.
[RESULTS] Among 96 patients included in this study, postoperative complications occurred in 69 (71.9%). Complication rates were significantly higher in patients with severe malnutrition (87.9% vs. 62.7%, = 0.015), low Geriatric Nutritional Risk Index (GNRI) (90.5% vs. 66.2%, = 0.023), low handgrip strength (91.7% vs. 61.5%, = 0.037), and low gait speed (90.5% vs. 63.6%, = 0.027). Major complications were linked to lower hemoglobin (Hb) (11.5 ± 1.9 vs. 12.8 ± 1.7 g/dL, = 0.001), lower hematocrit (HCT) (34.7 ± 5.4% vs. 38.4 ± 4.7%, = 0.001), and severe malnutrition (42.4% vs. 23.7%, = 0.05). Lower Hb, lower HCT, malnutrition, and greater waist circumference were associated with postoperative mortality. Longer hospital stays were correlated with weaker handgrip strength and slower gait speed.
[CONCLUSION] Preoperative malnutrition and impaired functional status are significant predictors of adverse postoperative outcomes in pancreatic cancer surgery.