Genome-wide analyses of cell-free DNA for therapeutic monitoring of patients with pancreatic cancer.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: pancreatic cancer can be challenging
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
We validated ARTEMIS-DELFI in patients with pancreatic cancer in the PACTO trial (NCT02767557). These analyses suggest that noninvasive mutation and fragmentation-based cfDNA approaches can identify therapeutic response of individuals with pancreatic cancer.
Determining response to therapy for patients with pancreatic cancer can be challenging.
- HR 0.12
APA
Hruban C, Bruhm DC, et al. (2025). Genome-wide analyses of cell-free DNA for therapeutic monitoring of patients with pancreatic cancer.. Science advances, 11(21), eads5002. https://doi.org/10.1126/sciadv.ads5002
MLA
Hruban C, et al.. "Genome-wide analyses of cell-free DNA for therapeutic monitoring of patients with pancreatic cancer.." Science advances, vol. 11, no. 21, 2025, pp. eads5002.
PMID
40397745 ↗
Abstract 한글 요약
Determining response to therapy for patients with pancreatic cancer can be challenging. We evaluated methods for assessing therapeutic response using cell-free DNA (cfDNA) in plasma from patients with metastatic pancreatic cancer in the CheckPAC trial (NCT02866383). Patients were evaluated before and after initiation of therapy using tumor-informed plasma whole-genome sequencing (WGMAF) and tumor-independent genome-wide cfDNA fragmentation profiles and repeat landscapes (ARTEMIS-DELFI). Using WGMAF, molecular responders had a median overall survival (OS) of 319 days compared to 126 days for nonresponders [hazard ratio (HR) = 0.29, 95% confidence interval (CI) = 0.11-0.79, = 0.011]. For ARTEMIS-DELFI, patients with low scores after therapy initiation had longer median OS than patients with high scores (233 versus 172 days, HR = 0.12, 95% CI = 0.046-0.31, < 0.0001). We validated ARTEMIS-DELFI in patients with pancreatic cancer in the PACTO trial (NCT02767557). These analyses suggest that noninvasive mutation and fragmentation-based cfDNA approaches can identify therapeutic response of individuals with pancreatic cancer.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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