The Role of ENHO in Pancreatic Adenocarcinoma: A Bioinformatics Approach.
[BACKGROUND] Pancreatic adenocarcinoma (PAAD) is an aggressive subtype of pancreatic cancer that is estimated to have a 5-year overall survival rate of only 13%.
- 95% CI 0.419-0.852
- HR 0.597
APA
Younis OM, Al-Sharif ZK, et al. (2025). The Role of ENHO in Pancreatic Adenocarcinoma: A Bioinformatics Approach.. Cancers, 17(13). https://doi.org/10.3390/cancers17132139
MLA
Younis OM, et al.. "The Role of ENHO in Pancreatic Adenocarcinoma: A Bioinformatics Approach.." Cancers, vol. 17, no. 13, 2025.
PMID
40647442
Abstract
[BACKGROUND] Pancreatic adenocarcinoma (PAAD) is an aggressive subtype of pancreatic cancer that is estimated to have a 5-year overall survival rate of only 13%. Most patients present with advanced disease with unpredictable outcomes. The identification of prognostic biomarkers is important to accurately stratify these patients.
[METHODS] We investigated the molecular and survival-related role of in PAAD by analyzing TGCA mRNA and miRNA data. Survival analysis was conducted using TIMER2.0, "survival", and "survminer". Gene set enrichment analysis was conducted using enrichr, while miRNA-mRNA interactions were identified using "multiMiR". Immune infiltration was assessed using CIBERSORT ABS and ImmuCellAI.
[RESULTS] We observed that was strikingly downregulated in PAAD tissues ( = 3.68 × 10), and patients with higher levels enjoyed significantly better overall survival (HR = 0.597; 95% CI: 0.419-0.852; < 0.01). Pathway analysis showed that genes co-upregulated with were enriched for insulin secretion and ion channel activity, whereas those co-downregulated were related to epithelial-mesenchymal transition and extracellular matrix remodeling. Higher also tracked with increased CD8 T-cell infiltration and correlated positively with PDCD1 and LAG3 but negatively with B7-H3, CD70, and NT5E.
[CONCLUSIONS] Our results point to a protective role for in pancreatic adenocarcinoma.
[METHODS] We investigated the molecular and survival-related role of in PAAD by analyzing TGCA mRNA and miRNA data. Survival analysis was conducted using TIMER2.0, "survival", and "survminer". Gene set enrichment analysis was conducted using enrichr, while miRNA-mRNA interactions were identified using "multiMiR". Immune infiltration was assessed using CIBERSORT ABS and ImmuCellAI.
[RESULTS] We observed that was strikingly downregulated in PAAD tissues ( = 3.68 × 10), and patients with higher levels enjoyed significantly better overall survival (HR = 0.597; 95% CI: 0.419-0.852; < 0.01). Pathway analysis showed that genes co-upregulated with were enriched for insulin secretion and ion channel activity, whereas those co-downregulated were related to epithelial-mesenchymal transition and extracellular matrix remodeling. Higher also tracked with increased CD8 T-cell infiltration and correlated positively with PDCD1 and LAG3 but negatively with B7-H3, CD70, and NT5E.
[CONCLUSIONS] Our results point to a protective role for in pancreatic adenocarcinoma.