A Cell-Surface-Targeted Fluorogenic Probe for Detection of Sulfatase 2 Activity.
1/5 보강
Sulfatase 2 (Sulf-2), an extracellular sulfatase that modulates the sulfation pattern of heparan sulfate proteoglycans (HSPGs), serves as a critical biomarker for various pathological conditions.
APA
Ding Y, Kowada T, et al. (2025). A Cell-Surface-Targeted Fluorogenic Probe for Detection of Sulfatase 2 Activity.. Bioconjugate chemistry, 36(9), 1980-1986. https://doi.org/10.1021/acs.bioconjchem.5c00251
MLA
Ding Y, et al.. "A Cell-Surface-Targeted Fluorogenic Probe for Detection of Sulfatase 2 Activity.." Bioconjugate chemistry, vol. 36, no. 9, 2025, pp. 1980-1986.
PMID
40848002 ↗
Abstract 한글 요약
Sulfatase 2 (Sulf-2), an extracellular sulfatase that modulates the sulfation pattern of heparan sulfate proteoglycans (HSPGs), serves as a critical biomarker for various pathological conditions. Monitoring Sulf-2 activity in living cell samples provides valuable insights for diagnostic applications and therapeutic evaluation of Sulf-2-related diseases. In this study, we developed a novel plasma-membrane-targeted fluorogenic probe, , to visualize the activity of Sulf-2 secreted by living cells. Upon incubation with Sulf-2-containing culture supernatant from pancreatic cancer cells, exhibited a significant increase in fluorescence at approximately 540 nm. Notably, allowed for time-lapse monitoring of endogenous Sulf-2 activity in living cancer cells overexpressing Sulf-2, demonstrating its potential as a valuable tool for Sulf-2-related cancer diagnostics and therapeutic research.
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