The Role of the Microbiome in Pancreas Cancer: The Evolving Influence of the Fungal Mycobiome.

The gut microbiome has been shown to impact the progression of pancreatic ductal adenocarcinoma and the tumor's response to therapy. Microbial dysbiosis or changes in the healthy gut microbiome has been implicated in pancreatic cancer patients and influences immune cell differentiation and cancer cell behavior in the tumor microenvironment. This article summarizes the key findings from studies investigating interactions between gut microbes and components of the tumor microenvironment, with a special focus on the oncogenic effects of the fungal mycobiome.