Canniprene B, a new prenylated dihydrostilbene with cytotoxic activities from the leaves of .
A new, canniprene B (), along with five known (- and -) dihydrostilbenes were isolated from the leaves of collected at CSIR - IIIM, Jammu, India.
APA
Singh R, Singh B, et al. (2025). Canniprene B, a new prenylated dihydrostilbene with cytotoxic activities from the leaves of .. Natural product research, 39(21), 6239-6247. https://doi.org/10.1080/14786419.2024.2376348
MLA
Singh R, et al.. "Canniprene B, a new prenylated dihydrostilbene with cytotoxic activities from the leaves of .." Natural product research, vol. 39, no. 21, 2025, pp. 6239-6247.
PMID
38989798
Abstract
A new, canniprene B (), along with five known (- and -) dihydrostilbenes were isolated from the leaves of collected at CSIR - IIIM, Jammu, India. Structures of all isolated compounds were elucidated by spectroscopic data analysis, including 1D and 2D NMR, and HR-ESI-MS. Canniprene B is a new prenylated dihydrostilbenes, a positional isomer of the known compound canniprene (). The cytotoxic activities of these compounds (-) were evaluated using the SRB assay against a panel of five human cancer cell lines. Notably, canniprene B () exhibited varying levels of cytotoxicity with IC values ranging from 2.5 to 33.52 μM, demonstrating the most potent activity against pancreatic cancer cells.
MeSH Terms
Humans; Plant Leaves; Cannabis; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Molecular Structure; Stilbenes; Drug Screening Assays, Antitumor; Prenylation; India; Magnetic Resonance Spectroscopy
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