Persistent Green Luminescence in Nanoparticles Functionalized with SARS-CoV-2 Spike Proteins: Virus-Like Particles Showing Active Targeting toward Selected Cells.
1/5 보강
The possibility of using nanoparticles (NPs) showing prolonged luminescence in the biosensing and bioimaging fields of science is now attracting increasing attention.
APA
Kuich P, Bazylińska U, et al. (2025). Persistent Green Luminescence in Nanoparticles Functionalized with SARS-CoV-2 Spike Proteins: Virus-Like Particles Showing Active Targeting toward Selected Cells.. ACS applied bio materials, 8(11), 10038-10049. https://doi.org/10.1021/acsabm.5c01355
MLA
Kuich P, et al.. "Persistent Green Luminescence in Nanoparticles Functionalized with SARS-CoV-2 Spike Proteins: Virus-Like Particles Showing Active Targeting toward Selected Cells.." ACS applied bio materials, vol. 8, no. 11, 2025, pp. 10038-10049.
PMID
41139303 ↗
Abstract 한글 요약
The possibility of using nanoparticles (NPs) showing prolonged luminescence in the biosensing and bioimaging fields of science is now attracting increasing attention. Such materials can help to overcome the problems of autofluorescence or increased photodamage because, for example, fractionated irradiance can be used in the light-induced generation of reactive oxygen species experiments. However, the carefully designed and engineered surface functionalization of those NPs is required for not only decreased toxicity but most importantly for active targeting toward selected cell types. As a solution, herein, we propose the construction of virus-like particles, which by mimicking the properties of real viruses can selectively enter cells with Toll-like receptors (TLRs), and additionally show afterglow emissive properties for enhanced biosensing and bioimaging applications. In particular, we have functionalized the surface of rod-like, Mn-doped, ZnGeO NPs, showing efficient green persistent luminescence, with so-called "artificial corona" composed of SARS-CoV-2 S1 spike proteins. The designed material preserved unique optical properties, including stable green luminescence with persistent decay time at the level of several dozen seconds, showed decreased cytotoxicity, and, most importantly, was taken up more readily by the human pancreatic cancer cell lines positive for TLRs with respect to the cell line negative for those markers.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.