Pancreatic cancer in 2025: Have we found a solution?

Pancreatic cancer is still one of the neoplasms with the worst prognosis. Late presentation at an unresectable or metastatic stage precluding surgery, aggressive biology, and resistance to antiblastic drugs make this disease a formidable foe. The authors, following the path already traced by the previous review, investigate and summarize the breakthroughs of recent years concerning this lethal disease. Areas of progress include improving prevention and early detection strategies, refining molecular understanding of pancreatic cancer, identifying more effective systemic therapies, and improving quality of life and surgical outcomes. No less important is the technological aspect that looks primarily at artificial intelligence.