Comprehensive Assessment of the Intrinsic Pancreatic Microbiome.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
109 patients.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[RESULTS] Sequencing of pancreatic tissue yielded few microbial reads regardless of diagnosis, and analysis of pancreatic tissue showed no difference in the abundance and composition of bacterial taxa between normal pancreas, IPMN, or PDAC…
[OBJECTIVE] To sought comprehensively profile tissue and cyst fluid in patients with benign, precancerous, and cancerous conditions of the pancreas to characterize the intrinsic pancreatic microbiome.
- 표본수 (n) 20
APA
Eckhoff AM, Fletcher AA, et al. (2025). Comprehensive Assessment of the Intrinsic Pancreatic Microbiome.. Annals of surgery, 282(6), 1060-1069. https://doi.org/10.1097/SLA.0000000000006299
MLA
Eckhoff AM, et al.. "Comprehensive Assessment of the Intrinsic Pancreatic Microbiome.." Annals of surgery, vol. 282, no. 6, 2025, pp. 1060-1069.
PMID
38623754 ↗
Abstract 한글 요약
[OBJECTIVE] To sought comprehensively profile tissue and cyst fluid in patients with benign, precancerous, and cancerous conditions of the pancreas to characterize the intrinsic pancreatic microbiome.
[BACKGROUND] Small studies in pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) have suggested that intrapancreatic microbial dysbiosis may drive malignant transformation.
[METHODS] Pancreatic samples were collected at the time of resection from 109 patients. Samples included tumor tissue (control, n = 20; IPMN, n = 20; PDAC, n = 19) and pancreatic cyst fluid (IPMN, n = 30; serous cystadenomas, n = 10; mucinous cystic neoplasm, n = 10). Assessment of bacterial DNA by quantitative polymerase chain reaction and 16S ribosomal RNA gene sequencing was performed. Downstream analyses determined the relative abundances of individual taxa between groups and compared intergroup diversity. Whole-genome sequencing data from 140 patients with PDAC in the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium were analyzed to validate findings.
[RESULTS] Sequencing of pancreatic tissue yielded few microbial reads regardless of diagnosis, and analysis of pancreatic tissue showed no difference in the abundance and composition of bacterial taxa between normal pancreas, IPMN, or PDAC groups. Low-grade and high-grade dysplasia IPMN were characterized by low bacterial abundances with no difference in tissue composition and a slight increase in Pseudomonas and Sediminibacterium in high-grade dysplasia cyst fluid. Decontamination analysis using the Clinical Proteomic Tumor Analysis Consortium database confirmed a low-biomass, low-diversity intrinsic pancreatic microbiome that did not differ by pathology.
[CONCLUSIONS] Our analysis of the pancreatic microbiome demonstrated very low intrinsic biomass that is relatively conserved across diverse neoplastic conditions and thus unlikely to drive malignant transformation.
[BACKGROUND] Small studies in pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) have suggested that intrapancreatic microbial dysbiosis may drive malignant transformation.
[METHODS] Pancreatic samples were collected at the time of resection from 109 patients. Samples included tumor tissue (control, n = 20; IPMN, n = 20; PDAC, n = 19) and pancreatic cyst fluid (IPMN, n = 30; serous cystadenomas, n = 10; mucinous cystic neoplasm, n = 10). Assessment of bacterial DNA by quantitative polymerase chain reaction and 16S ribosomal RNA gene sequencing was performed. Downstream analyses determined the relative abundances of individual taxa between groups and compared intergroup diversity. Whole-genome sequencing data from 140 patients with PDAC in the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium were analyzed to validate findings.
[RESULTS] Sequencing of pancreatic tissue yielded few microbial reads regardless of diagnosis, and analysis of pancreatic tissue showed no difference in the abundance and composition of bacterial taxa between normal pancreas, IPMN, or PDAC groups. Low-grade and high-grade dysplasia IPMN were characterized by low bacterial abundances with no difference in tissue composition and a slight increase in Pseudomonas and Sediminibacterium in high-grade dysplasia cyst fluid. Decontamination analysis using the Clinical Proteomic Tumor Analysis Consortium database confirmed a low-biomass, low-diversity intrinsic pancreatic microbiome that did not differ by pathology.
[CONCLUSIONS] Our analysis of the pancreatic microbiome demonstrated very low intrinsic biomass that is relatively conserved across diverse neoplastic conditions and thus unlikely to drive malignant transformation.
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