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Pneumocystis Pneumonia in a Patient Receiving Nab-paclitaxel Plus Gemcitabine for Unresectable Pancreatic Cancer.

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Internal medicine (Tokyo, Japan) 📖 저널 OA 81.9% 2024: 6/6 OA 2025: 37/56 OA 2026: 77/84 OA 2024~2026 2026 Vol.65(1) p. 162-166 OA
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Takano A, Himeji D, Shiiba R, Kushima N, Kinoshita E, Kamiike R

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We herein report the first case of Pneumocystis pneumonia (PCP) in a 78-year-old man with unresectable pancreatic head cancer who was treated with nab-paclitaxel plus gemcitabine.

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APA Takano A, Himeji D, et al. (2026). Pneumocystis Pneumonia in a Patient Receiving Nab-paclitaxel Plus Gemcitabine for Unresectable Pancreatic Cancer.. Internal medicine (Tokyo, Japan), 65(1), 162-166. https://doi.org/10.2169/internalmedicine.5315-25
MLA Takano A, et al.. "Pneumocystis Pneumonia in a Patient Receiving Nab-paclitaxel Plus Gemcitabine for Unresectable Pancreatic Cancer.." Internal medicine (Tokyo, Japan), vol. 65, no. 1, 2026, pp. 162-166.
PMID 40571611 ↗

Abstract

We herein report the first case of Pneumocystis pneumonia (PCP) in a 78-year-old man with unresectable pancreatic head cancer who was treated with nab-paclitaxel plus gemcitabine. The patient experienced fever during the second treatment course, and computed tomography revealed diffuse ground-glass opacities in the bilateral lungs. The β-D-glucan level was elevated. A polymerase chain reaction (PCR) assay of his bronchoalveolar lavage fluid specimen showed positivity for Pneumocystis jirovecii DNA. After treatment with corticosteroids and trimethoprim/sulfamethoxazole, the patient's general condition improved, followed by atovaquone. The administration of corticosteroids to prevent chemotherapy-induced nausea and vomiting (CINV) and lymphocytopenia due to chemotherapy may be therefore involved in the development of PCP.

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