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Intense FAPI Uptake of Pancreatic Tissue Can Mask the Tumor Activity of Pancreatic Cancer: The Importance of Dual-Tracer PET Imaging.

Molecular imaging and radionuclide therapy 2026 Vol.35(1) p. 70-72

Akgün E, Öztürk AE, Alçın G, Sevinç MM, Arslan E

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Fibroblast activation protein (FAPI), a type II transmembrane glycoprotein is a promising target to image epithelial originated cancers.

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APA Akgün E, Öztürk AE, et al. (2026). Intense FAPI Uptake of Pancreatic Tissue Can Mask the Tumor Activity of Pancreatic Cancer: The Importance of Dual-Tracer PET Imaging.. Molecular imaging and radionuclide therapy, 35(1), 70-72. https://doi.org/10.4274/mirt.galenos.2025.91069
MLA Akgün E, et al.. "Intense FAPI Uptake of Pancreatic Tissue Can Mask the Tumor Activity of Pancreatic Cancer: The Importance of Dual-Tracer PET Imaging.." Molecular imaging and radionuclide therapy, vol. 35, no. 1, 2026, pp. 70-72.
PMID 41536228

Abstract

Fibroblast activation protein (FAPI), a type II transmembrane glycoprotein is a promising target to image epithelial originated cancers. Pancreatic cancer is characterized with [Ga]Ga-FAPI-04 and F-fluorodeoxyglucose (F-FDG) uptake in varying degree. However physiologic uptake and uptake associated with acute/chronic pancreatitis makes interpretation challenging. We would like to present a case of pancreatic cancer whose tumor could not delineated from rest pancreatic tissue in [Ga]Ga-FAPI-04 positron emission tomography/computed tomography (PET/CT) images due to intense FAPI uptake in whole pancreas but more remarkable in F-FDG PET/CT images.

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