Clinical Significance of Cytokeratin 19-Fragments (CYFRA 21-1), Osteopontin (OPN) and Human Epididymis Protein 4 (HE4) in Pancreatic Adenocarcinoma.
단면연구
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: pancreatic cancer when compared to controls, 3
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Further, the CYFRA 21-1 levels were significantly higher in cases subjected to significant weight loss before admission.
Pancreatic cancer remains one of the most aggressive digestive neoplasms, especially due to late diagnosis.
- 연구 설계 cross-sectional
APA
Dima AC, Balaban DV, et al. (2026). Clinical Significance of Cytokeratin 19-Fragments (CYFRA 21-1), Osteopontin (OPN) and Human Epididymis Protein 4 (HE4) in Pancreatic Adenocarcinoma.. International journal of molecular sciences, 27(3). https://doi.org/10.3390/ijms27031562
MLA
Dima AC, et al.. "Clinical Significance of Cytokeratin 19-Fragments (CYFRA 21-1), Osteopontin (OPN) and Human Epididymis Protein 4 (HE4) in Pancreatic Adenocarcinoma.." International journal of molecular sciences, vol. 27, no. 3, 2026.
PMID
41683979 ↗
Abstract 한글 요약
Pancreatic cancer remains one of the most aggressive digestive neoplasms, especially due to late diagnosis. The aim of our study was to investigate cytokeratin-19 fragments (CYFRA 21-1), osteopontin (OPN), and human epididymis protein 4 (HE4) clinical significance in pancreatic adenocarcinoma. Our research is a single-center cross-sectional prospective study that included sixty hospitalized patients diagnosed with pancreatic adenocarcinoma and fourteen controls. CYFRA 21-1, OPN, and HE4 were tested in all participants using Luminex x MAP technology. Serum CYFRA 21-1 levels were weakly correlated with those of OPN (r = 0.302; = 0.009), HE4 (r = 0.485; < 0.001), and carbohydrate antigen (CA) 125 (r = 0.376; = 0.037). Similarly to CA 19-9 and CA 125, the serum OPN levels were higher in patients with pancreatic cancer when compared to controls, 3.37 (1.84; 9.12) ng/mL versus 1.59 (1.09; 2.51) ng/mL; = 0.003. However, in multivariate analysis, the OPN was not an independent predictor for pancreatic cancer. Further, the receiver operating characteristic (ROC) curve analysis identified CA 19-9 as the biomarker with the highest diagnostic accuracy, while CYFRA 21-1, OPN, and HE4 did not reach clinically meaningful results. Further, the CYFRA 21-1 levels were significantly higher in cases subjected to significant weight loss before admission.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Osteopontin
- Pancreatic Neoplasms
- Keratin-19
- WAP Four-Disulfide Core Domain Protein 2
- Male
- Female
- Antigens
- Neoplasm
- Middle Aged
- Aged
- Biomarkers
- Tumor
- Adenocarcinoma
- Cross-Sectional Studies
- Prospective Studies
- ROC Curve
- Proteins
- CA-19-9 Antigen
- Case-Control Studies
- Clinical Relevance
- CYFRA 21-1
- biomarker
- human epididymis protein 4
… 외 2개
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