Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents.
1/5 보강
Bergapten, a natural product from Maxim., exhibits anticancer, antibacterial, anti-inflammatory, and hypolipidemic effects.
APA
Yue Y, Liu JR, et al. (2026). Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents.. Journal of Asian natural products research, 28(3), 441-457. https://doi.org/10.1080/10286020.2025.2514692
MLA
Yue Y, et al.. "Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents.." Journal of Asian natural products research, vol. 28, no. 3, 2026, pp. 441-457.
PMID
40531172 ↗
Abstract 한글 요약
Bergapten, a natural product from Maxim., exhibits anticancer, antibacterial, anti-inflammatory, and hypolipidemic effects. A derivative, FSG-Y5 showed potent activity against pancreatic cancer cells PANC-1 (IC = 2.31 ± 0.25 µM) and CFPAC-1 (IC = 4.41 ± 0.47 µM), inhibiting their survival, migration, and invasion while inducing apoptosis Bax and Cleaved caspase-3 regulation. FSG-Y5 also suppressed pancreatic cancer organoids and zebrafish tumor growth in a concentration and time-dependent manner. These findings highlight bergapten derivatives as promising anticancer candidates, with FSG-Y5 as a potential anti-pancreatic cancer agent for further study.
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