← 뒤로

Tumor-specific targeting of a mitochondrial Kv1.3 channel inhibitor through conjugation to gastrin/cholecystokinin B receptor ligand strongly reduces pancreatic ductal adenocarcinoma in orthotopic models.

1/5 보강

Pharmacological research 📖 저널 OA 17.6% 2024~2026 2026 Vol.225() p. 108150 OA

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

추출되지 않음

I · Intervention 중재 / 시술

rapid metabolic cleavage, which prevented optimal uptake of the construct into PDAC

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

Efficacy studies revealed a reduction in mean tumor volume of up to 65 % in two independent orthotopic mouse models, with no tumor evident in some of the animals treated with the CCK2p-bound PAPTP construct. Our data suggest that tumor-specific targeting of small molecules may be a promising strategy for precision medicine against PDAC.

Parrasia S, Paoli C, Varanita T, Brillo V, Abdel-Salam MAL, Ongaro A

📖 무료 전문 🔓 OA PDF unpaywall · cc-by

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

Fatal error: Uncaught PDOException: SQLSTATE[42000]: Syntax error or access violation: 1064 You have an error in your SQL syntax; check the manual that corresponds to your MariaDB server version for the right syntax to use near 'JSON)) ORDER BY n_sources DESC LIMIT 6' at line 3 in /home/prsinsight/public_html/app/core/Database.php:33 Stack trace: #0 /home/prsinsight/public_html/app/core/Database.php(33): PDOStatement->execute() #1 /home/prsinsight/public_html/app/models/WikiPage.php(190): App\Core\Database::fetchAll() #2 /home/prsinsight/public_html/app/views/paper/show.php(671): App\Models\WikiPage::backlinksForPaper() #3 /home/prsinsight/public_html/app/core/View.php(32): include('...') #4 /home/prsinsight/public_html/app/core/View.php(15): App\Core\View->capture() #5 /home/prsinsight/public_html/app/core/Controller.php(21): App\Core\View->render() #6 /home/prsinsight/public_html/app/controllers/PaperController.php(372): App\Core\Controller->render() #7 [internal function]: App\Controllers\PaperController->show() #8 /home/prsinsight/public_html/app/core/Router.php(48): call_user_func_array() #9 /home/prsinsight/public_html/app/core/Router.php(34): App\Core\Router->call() #10 /home/prsinsight/public_html/index.php(286): App\Core\Router->dispatch() #11 {main} thrown in /home/prsinsight/public_html/app/core/Database.php on line 33