Survival by Treatment Recommendation and Treatment Receipt Among Older Adults with Localized Pancreatic Cancer.
가이드라인
2/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
409 patients (56.
I · Intervention 중재 / 시술
surgical resection (ages 65-74: 25
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] Receipt of recommended treatment-particularly surgical resection-was associated with improved survival and reduced cancer-specific mortality. The discordance between treatment recommendation and receipt, and differences by sex and race/ethnicity, highlight the need for equitable, individualized treatment decision-making beyond chronological age.
OpenAlex 토픽 ·
Pancreatic and Hepatic Oncology Research
Economic and Financial Impacts of Cancer
Frailty in Older Adults
[BACKGROUND] Localized pancreatic cancer can be treated with curative intent, but the survival impact of treatment recommendation versus actual receipt in older adults is not well characterized.
- 95% CI 22.4-29.2
- 연구 설계 cohort study
APA
Sebastian O. Ekenze, Charalampos Charalampous, Timothy M. Pawlik (2026). Survival by Treatment Recommendation and Treatment Receipt Among Older Adults with Localized Pancreatic Cancer.. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 102423. https://doi.org/10.1016/j.gassur.2026.102423
MLA
Sebastian O. Ekenze, et al.. "Survival by Treatment Recommendation and Treatment Receipt Among Older Adults with Localized Pancreatic Cancer.." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2026, pp. 102423.
PMID
41990989
Abstract
[BACKGROUND] Localized pancreatic cancer can be treated with curative intent, but the survival impact of treatment recommendation versus actual receipt in older adults is not well characterized. We aimed to quantify survival differences by treatment recommendation and receipt among adults aged ≥65 years with localized pancreatic cancer.
[METHODS] A population-based cohort study was conducted using data from 17 SEER registries, including adults aged ≥65 years diagnosed with localized pancreatic cancer from 2000-2022. Treatment was categorized by recommendation and receipt. Relative survival was estimated using the Ederer II method and cancer-specific mortality using Fine-Gray competing-risk models.
[RESULTS] Among 4,409 patients (56.6% female, 73.3% non-Hispanic White), 5-year relative survival was substantially higher for patients who underwent surgical resection (ages 65-74: 25.6%, 95% CI 22.4-29.2; ages 75-84: 18.5%, 95% CI 15.3-22.3) compared with individuals without a surgery recommendation (2.0%, 95% CI 1.2-3.2) or those recommended surgery but not treated (0.1%, 95% CI 0.0-1.3). Compared with nonreceipt or refusal of therapy, receipt of surgery (adjusted hazard ratio [AHR] 0.26, 95% CI 0.23-0.30), radiotherapy (AHR 0.82, 95% CI 0.67-1.00), and chemotherapy (AHR 0.67, 95% CI 0.63-0.72) were associated with lower cancer-specific mortality. Risk of death following an early pancreatic cancer diagnosis was lower among males (AHR 0.24, 95% CI 0.20-0.29) and lowest among non-Hispanic Asian/Pacific Islander patients (AHR 0.21, 95% CI 0.10-0.41).
[CONCLUSION] Receipt of recommended treatment-particularly surgical resection-was associated with improved survival and reduced cancer-specific mortality. The discordance between treatment recommendation and receipt, and differences by sex and race/ethnicity, highlight the need for equitable, individualized treatment decision-making beyond chronological age.
[METHODS] A population-based cohort study was conducted using data from 17 SEER registries, including adults aged ≥65 years diagnosed with localized pancreatic cancer from 2000-2022. Treatment was categorized by recommendation and receipt. Relative survival was estimated using the Ederer II method and cancer-specific mortality using Fine-Gray competing-risk models.
[RESULTS] Among 4,409 patients (56.6% female, 73.3% non-Hispanic White), 5-year relative survival was substantially higher for patients who underwent surgical resection (ages 65-74: 25.6%, 95% CI 22.4-29.2; ages 75-84: 18.5%, 95% CI 15.3-22.3) compared with individuals without a surgery recommendation (2.0%, 95% CI 1.2-3.2) or those recommended surgery but not treated (0.1%, 95% CI 0.0-1.3). Compared with nonreceipt or refusal of therapy, receipt of surgery (adjusted hazard ratio [AHR] 0.26, 95% CI 0.23-0.30), radiotherapy (AHR 0.82, 95% CI 0.67-1.00), and chemotherapy (AHR 0.67, 95% CI 0.63-0.72) were associated with lower cancer-specific mortality. Risk of death following an early pancreatic cancer diagnosis was lower among males (AHR 0.24, 95% CI 0.20-0.29) and lowest among non-Hispanic Asian/Pacific Islander patients (AHR 0.21, 95% CI 0.10-0.41).
[CONCLUSION] Receipt of recommended treatment-particularly surgical resection-was associated with improved survival and reduced cancer-specific mortality. The discordance between treatment recommendation and receipt, and differences by sex and race/ethnicity, highlight the need for equitable, individualized treatment decision-making beyond chronological age.