The Goddard score for emphysema predicts the postoperative prognosis in pancreatic cancer.
TL;DR
The Goddard score, a simple radiological index of emphysema, may serve as a novel preoperative prognostic indicator in patients undergoing pancreatic cancer surgery and may serve as a novel preoperative prognostic indicator in patients undergoing postoperative complications.
OpenAlex 토픽 ·
Inflammatory Biomarkers in Disease Prognosis
Pancreatic and Hepatic Oncology Research
Lung Cancer Diagnosis and Treatment
The Goddard score, a simple radiological index of emphysema, may serve as a novel preoperative prognostic indicator in patients undergoing pancreatic cancer surgery and may serve as a novel preoperati
- p-value p = 0.01
- p-value p = 0.02
- 95% CI 1.09-2.97
APA
Yuta Yamada, Kenei Furukawa, et al. (2026). The Goddard score for emphysema predicts the postoperative prognosis in pancreatic cancer.. Surgery today, 56(5), 736-744. https://doi.org/10.1007/s00595-025-03188-7
MLA
Yuta Yamada, et al.. "The Goddard score for emphysema predicts the postoperative prognosis in pancreatic cancer.." Surgery today, vol. 56, no. 5, 2026, pp. 736-744.
PMID
41251761
Abstract
[PURPOSE] Chronic inflammation contributes to carcinogenesis and pulmonary emphysema is characterized by chronic pulmonary inflammation. We hypothesized that the severity of emphysema, quantitatively assessed using the Goddard score (GS), correlates with outcomes following surgical treatment for pancreatic cancer.
[METHODS] We retrospectively analyzed 191 patients who underwent surgery for pancreatic cancer between 2013 and 2022. GS was assessed using routine preoperative computed tomography. Univariate and multivariate analyses were performed to evaluate the impact of GS on oncological outcomes.
[RESULTS] A high GS (≥ 7) was identified in 46 (24.1%) patients, who were significantly older and had a lower body mass index than patients with a low GS. In the multivariate analysis, a high GS emerged as an independent predictor of both a worse disease-free survival (DFS) (hazard ratio [HR], 1.58; 95% confidence interval [CI], 1.06-2.36; p = 0.01) and worse overall survival (OS) (HR, 1.80; 95% CI, 1.09-2.97; p = 0.02). Other independent risk factors included a poor DFS, sarcopenia, lymph node metastasis, poor tumor differentiation, poor OS, poor tumor differentiation, lack of adjuvant chemotherapy, and postoperative complications.
[CONCLUSION] The GS, a simple radiological index of emphysema, may serve as a novel preoperative prognostic indicator in patients undergoing pancreatic cancer surgery.
[METHODS] We retrospectively analyzed 191 patients who underwent surgery for pancreatic cancer between 2013 and 2022. GS was assessed using routine preoperative computed tomography. Univariate and multivariate analyses were performed to evaluate the impact of GS on oncological outcomes.
[RESULTS] A high GS (≥ 7) was identified in 46 (24.1%) patients, who were significantly older and had a lower body mass index than patients with a low GS. In the multivariate analysis, a high GS emerged as an independent predictor of both a worse disease-free survival (DFS) (hazard ratio [HR], 1.58; 95% confidence interval [CI], 1.06-2.36; p = 0.01) and worse overall survival (OS) (HR, 1.80; 95% CI, 1.09-2.97; p = 0.02). Other independent risk factors included a poor DFS, sarcopenia, lymph node metastasis, poor tumor differentiation, poor OS, poor tumor differentiation, lack of adjuvant chemotherapy, and postoperative complications.
[CONCLUSION] The GS, a simple radiological index of emphysema, may serve as a novel preoperative prognostic indicator in patients undergoing pancreatic cancer surgery.
MeSH Terms
Humans; Pancreatic Neoplasms; Male; Female; Prognosis; Aged; Retrospective Studies; Middle Aged; Postoperative Complications; Tomography, X-Ray Computed; Severity of Illness Index; Risk Factors; Survival Rate; Disease-Free Survival; Pulmonary Emphysema; Aged, 80 and over; Emphysema; Postoperative Period
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