TGF-β, to target or not to target; to prevent thyroid cancer progression?
1/5 보강
Thyroid cancer (TC) is a common endocrine cancer with a rising incidence.
APA
Karnik I, Sutherland R, et al. (2022). TGF-β, to target or not to target; to prevent thyroid cancer progression?. Biochimica et biophysica acta. Reviews on cancer, 1877(4), 188752. https://doi.org/10.1016/j.bbcan.2022.188752
MLA
Karnik I, et al.. "TGF-β, to target or not to target; to prevent thyroid cancer progression?." Biochimica et biophysica acta. Reviews on cancer, vol. 1877, no. 4, 2022, pp. 188752.
PMID
35728736 ↗
Abstract 한글 요약
Thyroid cancer (TC) is a common endocrine cancer with a rising incidence. Current treatment fails to eliminate aggressive thyroid tumours, prompting an investigation into the processes that cause disease progression. In this review, we provide insight into TGF-β driven epithelial to mesenchymal transition (EMT), summarizing the current literature surrounding thyroid carcinogenesis, and discuss the potential for therapeutic strategies targeting the TGF-β signalling pathway. Understanding the underlying mechanisms that regulate cancer stem cell (CSC) growth and TGF-β signalling may provide novel therapeutic approaches for highly resistant TCs.
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