Vitamin D Status and VDR Polymorphisms as Prognostic Factors in Differentiated Thyroid Carcinoma.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: thyroid cancer (p<0
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The Ff genotype of FokI was also associated with multifocality, invasive pattern, and risk for local metastasis. [CONCLUSION] The VDR gene polymorphism FokI may be associated with the risk of thyroid cancer and its more aggressive forms.
[BACKGROUND/AIM] Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms are involved in a variety of biological processes including cell proliferation, apoptosis, and adhesion in maligna
- 표본수 (n) 113
- p-value p=0.03
- p-value p<0.001
APA
Cocolos AM, Muresan A, et al. (2022). Vitamin D Status and VDR Polymorphisms as Prognostic Factors in Differentiated Thyroid Carcinoma.. In vivo (Athens, Greece), 36(5), 2434-2441. https://doi.org/10.21873/invivo.12977
MLA
Cocolos AM, et al.. "Vitamin D Status and VDR Polymorphisms as Prognostic Factors in Differentiated Thyroid Carcinoma.." In vivo (Athens, Greece), vol. 36, no. 5, 2022, pp. 2434-2441.
PMID
36099120 ↗
Abstract 한글 요약
[BACKGROUND/AIM] Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms are involved in a variety of biological processes including cell proliferation, apoptosis, and adhesion in malignant tumors. This study investigated whether vitamin D levels and genetic variations of VDR are risk factors for thyroid cancer.
[PATIENTS AND METHODS] Patients who underwent surgery for differentiated thyroid carcinoma (n=113) and those with benign thyroid pathology (n=150) were genotyped for VDR gene polymorphisms (ApaI, TaqI, FokI, and BsmI) and their 25(OH)D levels were simultaneously measured. Demographic data and histopathologic reports were also acquired for all patients.
[RESULTS] Vitamin D levels were significantly lower in the thyroid cancer group (p=0.03). FokI and TaqI polymorphisms were more frequent in the thyroid cancer patients (p<0.001). Compared to control, the proportion of the FokI Ff genotype was increased (p<0.0006) and the proportion of the TaqI Tt genotype was also higher among patients with thyroid cancer (p<0.0001). The Ff genotype of FokI was also associated with multifocality, invasive pattern, and risk for local metastasis.
[CONCLUSION] The VDR gene polymorphism FokI may be associated with the risk of thyroid cancer and its more aggressive forms.
[PATIENTS AND METHODS] Patients who underwent surgery for differentiated thyroid carcinoma (n=113) and those with benign thyroid pathology (n=150) were genotyped for VDR gene polymorphisms (ApaI, TaqI, FokI, and BsmI) and their 25(OH)D levels were simultaneously measured. Demographic data and histopathologic reports were also acquired for all patients.
[RESULTS] Vitamin D levels were significantly lower in the thyroid cancer group (p=0.03). FokI and TaqI polymorphisms were more frequent in the thyroid cancer patients (p<0.001). Compared to control, the proportion of the FokI Ff genotype was increased (p<0.0006) and the proportion of the TaqI Tt genotype was also higher among patients with thyroid cancer (p<0.0001). The Ff genotype of FokI was also associated with multifocality, invasive pattern, and risk for local metastasis.
[CONCLUSION] The VDR gene polymorphism FokI may be associated with the risk of thyroid cancer and its more aggressive forms.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
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