Effect of regulating the gene on recurrence of thyroid tumor and its molecular mechanism.

[BACKGROUND] Thyroid blood vessels and nerves are rich, and their anatomical and physiological structures are complex. Surgery often fails to eradicate the tumor, which has a serious negative impact on the surgical outcomes and patient prognosis. Therefore, it is important to accurately predict the recurrence rate of thyroid cancer.

[METHODS] Based on bioinformatics analysis, the highly expressed transcription factors and differential genes in thyroid carcinoma (THCA) were obtained. Kaplan-Meier survival analysis was used to analyze the clinical effects of as well as on the recurrence of THCA patients. The effect of on expression was explored using cell experiments. Other experiments were conducted to reveal the interaction between and and their functions in THCA progression, such as cell proliferation and cell cycle.

[RESULTS] was overexpressed in recurrent THCA tissue compared with that in adjacent normal tissue. and were identified as the key risk factors for THCA recurrence as well as survival. Knockdown of and can inhibit THCA cell proliferation and arrest THCA cells in the G1 phase. Inhibiting decreased expression in THCA cells, whereas overexpressing had the opposite result. knockdown eliminated -induced proliferation of THCA cells in vitro, indicating that -induced THCA cell proliferation was dependent on increased expression.

[CONCLUSIONS] We identified as an underlying diagnostic biomarker in THCA recurrence patients. The -SRRM2 axis mediates human THCA recurrence progression and is an underlying target for THCA treatment.