rearrangements are relevant to histopathologic subtypes and clinicopathological features in Thai papillary thyroid carcinoma patients.

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer The gene rearrangements :: and :: are the most common gene rearrangements in PTC patients. Different :: rearrangements are associated with different PTC phenotypes. Eighty-three formalin-fixed paraffin-embedded (FFPE) PTC samples were examined. The prevalence and expression levels of :: and :: were determined using semi-quantitative polymerase chain reaction (qRT-PCR). The association of these rearrangements with clinicopathological data was investigated. The presence of :: rearrangement was significantly associated with the classic subtype and absence of angio/lymphatic invasion ( < 0.05). While :: was associated with the tall-cell subtype, and presence of angio/lymphatic invasion and lymph node metastasis ( < 0.05). Multivariate analysis demonstrated that an absence of extrathyroidal extension and extranodal extension were independent predictive factors for ::, whereas the tall-cell subtype, large tumor size, angioinvasion, lymphatic invasion and perineural invasion were independent predictive factors for :: ( < 0.05). However, the mRNA expression level of :: and of :: were not significantly associated with clinicopathological data. :: was correlated with an innocent PTC subtype and characteristics, but :: correlated with an aggressive phenotype of PTC. Therefore, these rearrangements strongly associated with clinicopathological phenotypes and can be used as predictive markers in PTC patients.