Case Report: Identification of a novel fusion co-existing with fusion in papillary thyroid carcinoma.
증례보고
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: papillary thyroid carcinoma
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
In conclusion, we present the first case of a novel fusion co-existing with a known fusion in thyroid cancer.
fusions are validated oncogenic drivers of various adult and pediatric tumor types, including thyroid cancer, and serve as a therapeutic target.
APA
Yu QX, Zhao WJ, et al. (2023). Case Report: Identification of a novel fusion co-existing with fusion in papillary thyroid carcinoma.. Frontiers in oncology, 13, 1123812. https://doi.org/10.3389/fonc.2023.1123812
MLA
Yu QX, et al.. "Case Report: Identification of a novel fusion co-existing with fusion in papillary thyroid carcinoma.." Frontiers in oncology, vol. 13, 2023, pp. 1123812.
PMID
37188179 ↗
Abstract 한글 요약
fusions are validated oncogenic drivers of various adult and pediatric tumor types, including thyroid cancer, and serve as a therapeutic target. Recently, tropomyosin receptor kinase (TRK) inhibitors, such as entrectinib and larotrectinib, display promising therapeutic efficacy in -positive solid tumors. Although some fusion partners have been identified in thyroid cancer, the spectrum of fusion is not fully characterized. In this study, a dual fusion was identified by targeted RNA-Seq in a 47-year-old female patient with papillary thyroid carcinoma. The patient harbors a novel in-frame fusion between exon 13 and exon 2, co-existing with a known in-frame fusion between exon 4 and exon 14. The dual fusion was validated by Sanger sequencing and fluorescence hybridization (FISH) but lack TRK protein expression as defined by pan-TRK immunohistochemistry (IHC). We supposed the pan-TRK IHC result to be falsely negative. In conclusion, we present the first case of a novel fusion co-existing with a known fusion in thyroid cancer. These findings extend the spectrum of translocation partners in fusion, and the effect of dual fusion on TRK inhibitor therapy and prognosis needs long-term follow-up.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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