Comparison of tumor-agnostic and tumor-specific clinical oncology trial designs: a systematic review and meta-analysis.
메타분석
1/5 보강
To examine whether tumor-specific and tumor-agnostic oncology trials produce comparable estimates of objective response rate (ORR) in -altered cancers.
- p-value p = 0.05
APA
Farid-Kapadia M, Barton M, et al. (2023). Comparison of tumor-agnostic and tumor-specific clinical oncology trial designs: a systematic review and meta-analysis.. Future oncology (London, England), 19(25), 1741-1752. https://doi.org/10.2217/fon-2022-0974
MLA
Farid-Kapadia M, et al.. "Comparison of tumor-agnostic and tumor-specific clinical oncology trial designs: a systematic review and meta-analysis.." Future oncology (London, England), vol. 19, no. 25, 2023, pp. 1741-1752.
PMID
37283038 ↗
Abstract 한글 요약
To examine whether tumor-specific and tumor-agnostic oncology trials produce comparable estimates of objective response rate (ORR) in -altered cancers. Electronic database searches were performed to identify phase I-III clinical trials testing tyrosine kinase inhibitors from 2000 to 2021. A random-effects model was used to pool ORRs. A total of 22 cohorts from five tumor-agnostic trials and 41 cohorts from 27 tumor-specific trials had published ORRs. There was no significant difference between pooled ORRs from either trial design for multitumor analyses (37 vs 50%; p = 0.05); thyroid cancer (57 vs 33%; p = 0.10); non-small-cell lung cancer (39 vs 53%; p = 0.18); or melanoma (55 vs 51%; p = 0.58). For -altered advanced cancers, tumor-agnostic trials do not yield substantially different results from tumor-specific trials.
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