LncRNA SOCS2-AS1 promotes the progression of papillary thyroid cancer by destabilizing p53 protein.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: a higher level of SOCS2-AS1 had a poor prognosis
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
we demonstrated that SOCS2-AS1 regulates the rate of fatty acid oxidation (FAO) in PTC cells.
Long noncoding RNAs (lncRNAs) have been shown to contribute to tumorigenesis and cancer progression.
APA
Zhang X, Zhang X, et al. (2023). LncRNA SOCS2-AS1 promotes the progression of papillary thyroid cancer by destabilizing p53 protein.. Biochemical and biophysical research communications, 669, 95-102. https://doi.org/10.1016/j.bbrc.2023.05.080
MLA
Zhang X, et al.. "LncRNA SOCS2-AS1 promotes the progression of papillary thyroid cancer by destabilizing p53 protein.." Biochemical and biophysical research communications, vol. 669, 2023, pp. 95-102.
PMID
37267865 ↗
Abstract 한글 요약
Long noncoding RNAs (lncRNAs) have been shown to contribute to tumorigenesis and cancer progression. However, neither the dysregulation nor the functions of anti-sense lncRNAs in papillary thyroid carcinoma (PTC) have been exhaustively studied. In this study, we accessed The Cancer Genome Atlas (TCGA) database and discovered that the natural antisense lncRNA SOCS2-AS1 is highly expressed in PTC and that patients with a higher level of SOCS2-AS1 had a poor prognosis. Furthermore, loss- and gain-function assays demonstrated that SOCS2-AS1 promotes PTC cell proliferation and growth both in vitro and in vivo. In addition, we demonstrated that SOCS2-AS1 regulates the rate of fatty acid oxidation (FAO) in PTC cells. Analysis of the mechanism revealed that SOCS2-AS1 binds to p53 and controls its stability in PTC cell lines. Overall, our findings showed that the natural antisense lncRNA SOCS2-AS1 stimulates the degradation of p53 and enhances PTC cell proliferation and the FAO rate.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Thyroid Cancer
- Papillary
- RNA
- Long Noncoding
- Thyroid Neoplasms
- Tumor Suppressor Protein p53
- Antisense
- Cell Proliferation
- Gene Expression Regulation
- Neoplastic
- Cell Line
- Tumor
- MicroRNAs
- Cell Movement
- Suppressor of Cytokine Signaling Proteins
- Cell proliferation
- Fatty acid oxidation
- LncRNA
- SOCS2-AS1
- p53 signaling
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