Causal associations between schizophrenia and cancers risk: a Mendelian randomization study.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: schizophrenia compared to the general population
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] This study conducted a two-sample MR analysis and discovered a positive causal relationship between schizophrenia and breast, ovarian, thyroid, lung, and colorectal cancers. On the other hand, an inverse causal relationship was found between schizophrenia and malignant neoplasm of the stomach.
[BACKGROUND] Previous observational studies have reported inconsistent findings regarding the incidence of cancer in patients with schizophrenia compared to the general population.
- OR 1.5482
APA
Zhou K, Zhu L, et al. (2023). Causal associations between schizophrenia and cancers risk: a Mendelian randomization study.. Frontiers in oncology, 13, 1258015. https://doi.org/10.3389/fonc.2023.1258015
MLA
Zhou K, et al.. "Causal associations between schizophrenia and cancers risk: a Mendelian randomization study.." Frontiers in oncology, vol. 13, 2023, pp. 1258015.
PMID
38044984 ↗
Abstract 한글 요약
[BACKGROUND] Previous observational studies have reported inconsistent findings regarding the incidence of cancer in patients with schizophrenia compared to the general population. The causal relationship between schizophrenia and cancer remains unclear and requires further investigation.
[OBJECTIVE] To investigate the causal relationship between schizophrenia and cancer.
[METHODS] In this study, a two-sample Mendelian randomization (MR) analysis was conducted using publicly available genome-wide association studies to determine the causal relationship. The effect estimates were calculated using the random-effects inverse-variance-weighted method.
[RESULTS] We determined a causal relationship between genetic predisposition to schizophrenia and cancer, with schizophrenia increasing lung cancer (odds ratio (OR) = 1.0007; 95% confidence interval (CI), 1.0001-1.0013; = 0.0192), thyroid cancer (OR = 1.5482; CI, 1.1112-2.1569; =0.0098),colorectal cancer (OR = 1.0009; CI, 1.0001-1.0018; = 0.0344), ovarian cancer (OR = 1.0770; CI, 1.0352-1.1203; = 0.0002), breast cancer (OR = 1.0011; CI, 1.0001- 1.0022; =0.0352) and reduced the risk of malignant neoplasm of the stomach (OR = 0.8502; CI, 0.7230-0.9998; = 0.0496).
[CONCLUSIONS] This study conducted a two-sample MR analysis and discovered a positive causal relationship between schizophrenia and breast, ovarian, thyroid, lung, and colorectal cancers. On the other hand, an inverse causal relationship was found between schizophrenia and malignant neoplasm of the stomach.
[OBJECTIVE] To investigate the causal relationship between schizophrenia and cancer.
[METHODS] In this study, a two-sample Mendelian randomization (MR) analysis was conducted using publicly available genome-wide association studies to determine the causal relationship. The effect estimates were calculated using the random-effects inverse-variance-weighted method.
[RESULTS] We determined a causal relationship between genetic predisposition to schizophrenia and cancer, with schizophrenia increasing lung cancer (odds ratio (OR) = 1.0007; 95% confidence interval (CI), 1.0001-1.0013; = 0.0192), thyroid cancer (OR = 1.5482; CI, 1.1112-2.1569; =0.0098),colorectal cancer (OR = 1.0009; CI, 1.0001-1.0018; = 0.0344), ovarian cancer (OR = 1.0770; CI, 1.0352-1.1203; = 0.0002), breast cancer (OR = 1.0011; CI, 1.0001- 1.0022; =0.0352) and reduced the risk of malignant neoplasm of the stomach (OR = 0.8502; CI, 0.7230-0.9998; = 0.0496).
[CONCLUSIONS] This study conducted a two-sample MR analysis and discovered a positive causal relationship between schizophrenia and breast, ovarian, thyroid, lung, and colorectal cancers. On the other hand, an inverse causal relationship was found between schizophrenia and malignant neoplasm of the stomach.
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