BRAF Mutation Analysis in Fine-Needle Aspiration Cytology of Fixed Slide Specimens in Patients with Papillary Thyroid Carcinoma.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
19 patients with Bethesda II to VI reports were used to detect BRAF mutation by pyrosequencing of extracted DNA.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] BRAF mutation analysis can be performed on fixed fine needle aspiration cytology specimens. Although the frequency of the mutation is higher in specimens with higher Bethesda category scores, it could support clinical decision-making in thyroid nodules with intermediate Bethesda category scores.
[BACKGROUND] Papillary thyroid carcinoma is the most frequent type of thyroid cancer.
APA
Cheraghi S, Honardoost M, et al. (2024). BRAF Mutation Analysis in Fine-Needle Aspiration Cytology of Fixed Slide Specimens in Patients with Papillary Thyroid Carcinoma.. Medical journal of the Islamic Republic of Iran, 38, 83. https://doi.org/10.47176/mjiri.38.83
MLA
Cheraghi S, et al.. "BRAF Mutation Analysis in Fine-Needle Aspiration Cytology of Fixed Slide Specimens in Patients with Papillary Thyroid Carcinoma.." Medical journal of the Islamic Republic of Iran, vol. 38, 2024, pp. 83.
PMID
39678775 ↗
Abstract 한글 요약
[BACKGROUND] Papillary thyroid carcinoma is the most frequent type of thyroid cancer. The BRAF mutation is associated with tumor progression. We explored the utility of the BRAF molecular testing on fine needle aspiration fixed specimens of patients with confirmed diagnoses of papillary thyroid carcinoma.
[METHODS] Fixed thyroid cytology slide specimens of 19 patients with Bethesda II to VI reports were used to detect BRAF mutation by pyrosequencing of extracted DNA.
[RESULTS] BRAF mutation was detected in 25% of the specimens with Bethesda category III and IV nodules and in 73% of the nodules with Bethesda category V and VI.
[CONCLUSION] BRAF mutation analysis can be performed on fixed fine needle aspiration cytology specimens. Although the frequency of the mutation is higher in specimens with higher Bethesda category scores, it could support clinical decision-making in thyroid nodules with intermediate Bethesda category scores.
[METHODS] Fixed thyroid cytology slide specimens of 19 patients with Bethesda II to VI reports were used to detect BRAF mutation by pyrosequencing of extracted DNA.
[RESULTS] BRAF mutation was detected in 25% of the specimens with Bethesda category III and IV nodules and in 73% of the nodules with Bethesda category V and VI.
[CONCLUSION] BRAF mutation analysis can be performed on fixed fine needle aspiration cytology specimens. Although the frequency of the mutation is higher in specimens with higher Bethesda category scores, it could support clinical decision-making in thyroid nodules with intermediate Bethesda category scores.
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