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A case of T-cell large granular lymphocytic leukemia with autoimmune hemolytic anemia and literature review.

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American journal of translational research 2024 Vol.16(10) p. 5735-5742
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Wang SY, Li Y

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T-cell large granular lymphocyte leukemia (T-LGLL), which is associated with autoimmune diseases, has been described.

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APA Wang SY, Li Y (2024). A case of T-cell large granular lymphocytic leukemia with autoimmune hemolytic anemia and literature review.. American journal of translational research, 16(10), 5735-5742. https://doi.org/10.62347/URFI7647
MLA Wang SY, et al.. "A case of T-cell large granular lymphocytic leukemia with autoimmune hemolytic anemia and literature review.." American journal of translational research, vol. 16, no. 10, 2024, pp. 5735-5742.
PMID 39544786
DOI 10.62347/URFI7647

Abstract

T-cell large granular lymphocyte leukemia (T-LGLL), which is associated with autoimmune diseases, has been described. However, T-LGLL with B-cell dyscrasias presenting as autoimmune hemolytic anemia has been less frequently reported. Here, we report a rare case of combined papillary thyroid cancer (PTC), discuss the possible relationship between autoimmune hemolytic anemia (AIHA) and TLGLL, and review the literature. The patient presented with pancytopenia and systemic jaundice. Fortunately, the patient responded well to hormone and immunosuppressive (methotrexate) therapy. However, this insight is based on one rare case, and the pathogenesis of this disease requires further clinical research for clarification.

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