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Thyroglobulin and calcitonin measurements: pitfalls and future perspectives.

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The Journal of endocrinology 2025 Vol.264(1)
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Mater A, Boelen A, Heijboer AC, Hillebrand JJ

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Thyroid cancer is the most prevalent endocrine cancer, and the prognosis depends on the type and stage of cancer at the time of discovery.

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APA Mater A, Boelen A, et al. (2025). Thyroglobulin and calcitonin measurements: pitfalls and future perspectives.. The Journal of endocrinology, 264(1). https://doi.org/10.1530/JOE-24-0156
MLA Mater A, et al.. "Thyroglobulin and calcitonin measurements: pitfalls and future perspectives.." The Journal of endocrinology, vol. 264, no. 1, 2025.
PMID 39437178 ↗
DOI 10.1530/JOE-24-0156

Abstract

Thyroid cancer is the most prevalent endocrine cancer, and the prognosis depends on the type and stage of cancer at the time of discovery. The treatment involves (hemi-)thyroidectomy, possibly followed by additional therapeutic options. After treatment, patients are monitored using serum concentrations of endocrine tumour markers: thyroglobulin (Tg) in case of differentiated cancer and calcitonin in case of medullary thyroid cancer. Measuring Tg and calcitonin concentrations in serum may be challenging. In this review, we provide a complete overview of the evolution in laboratory measurements of Tg and calcitonin, with an emphasis on (pre-)analytical challenges and potential approaches to overcome current pitfalls.

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