Focal Radioiodine Uptake in the Lower Limb: A Benign Mimicker of Metastasis in High-risk Differentiated Thyroid Cancer.
A 55-year-old man with high-risk papillary thyroid cancer underwent a second round of radioiodine therapy due to lung and lymph node metastases.
APA
Ahmadi M, Sahafi P, et al. (2025). Focal Radioiodine Uptake in the Lower Limb: A Benign Mimicker of Metastasis in High-risk Differentiated Thyroid Cancer.. Clinical nuclear medicine. https://doi.org/10.1097/RLU.0000000000006136
MLA
Ahmadi M, et al.. "Focal Radioiodine Uptake in the Lower Limb: A Benign Mimicker of Metastasis in High-risk Differentiated Thyroid Cancer.." Clinical nuclear medicine, 2025.
PMID
40958156
Abstract
A 55-year-old man with high-risk papillary thyroid cancer underwent a second round of radioiodine therapy due to lung and lymph node metastases. A follow-up whole-body scan showed a new focal area of radioiodine uptake in the right lower limb, which was absent in previous scan and remained despite skin decontamination. Upon examination, a posttraumatic scab was found on the right leg from a fall 5 days prior. SPECT/CT imaging and scab healing during follow-up effectively ruled out bone and skin metastases. This case underscores the need to recognize false-positive radioiodine uptake in differentiated thyroid cancer for improved diagnostic accuracy and patient care.
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