Undetectable Serum Thyroglobulin in Patients With Differentiated Thyroid Cancer: Antithyroglobulin Antibodies, Assay Limitation, or Other?
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
42 patients, 87% had detectable Tg in the FNAB washout fluid by Tg-IA, and 83% by Tg mass spectrometry (Tg-MS) measurement.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The absence of serum Tg could not be completely explained by the presence of TgAb. These results suggest that, for a subset of patients with DTC LN metastases, the absence of detectable Tg in serum does not appear to be due to analytical limitations of current Tg assays or the presence of TgAb interference.
[OBJECTIVE] To determine why some patients with differentiated thyroid cancer (DTC) lymph node (LN) metastases do not have detectable serum thyroglobulin (Tg).
APA
Andress B, Miller SA, et al. (2025). Undetectable Serum Thyroglobulin in Patients With Differentiated Thyroid Cancer: Antithyroglobulin Antibodies, Assay Limitation, or Other?. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 31(10), 1286-1291. https://doi.org/10.1016/j.eprac.2025.06.001
MLA
Andress B, et al.. "Undetectable Serum Thyroglobulin in Patients With Differentiated Thyroid Cancer: Antithyroglobulin Antibodies, Assay Limitation, or Other?." Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, vol. 31, no. 10, 2025, pp. 1286-1291.
PMID
40499758 ↗
Abstract 한글 요약
[OBJECTIVE] To determine why some patients with differentiated thyroid cancer (DTC) lymph node (LN) metastases do not have detectable serum thyroglobulin (Tg).
[METHODS] Fine needle aspiration biopsy (FNAB) washout fluid from patients with DTC LN metastases and undetectable serum Tg measurement by immunoassay (Tg-IA) were evaluated for the presence of Tg and anti-Tg antibodies (TgAbs). Spike-recovery experiments in serum were performed to assess the reason for undetectable Tg.
[RESULTS] Of the 42 patients, 87% had detectable Tg in the FNAB washout fluid by Tg-IA, and 83% by Tg mass spectrometry (Tg-MS) measurement. Seventy-six percent of these patients had detectable serum TgAb, while 26% did not. Tg spike-recovery experiments performed on the TgAb+ (positive) serum samples showed decreased Tg recovery by Tg-IA but not by Tg-MS (Tg-IA mean, range: 50%, 12%-84%; Tg-MS 96%, 70%-117%). In TgAb- (negative) serum samples no interference was observed (>94% recoveries). No difference in FNAB washout fluid Tg recovery between TgAb- and TgAb+ patients was observed.
[CONCLUSION] Tg was detected by both Tg-IA and Tg-MS methods in the majority of FNAB washout fluid from patients with DTC LN metastases who exhibited undetectable serum Tg by Tg-IA and Tg-MS. The absence of serum Tg could not be completely explained by the presence of TgAb. These results suggest that, for a subset of patients with DTC LN metastases, the absence of detectable Tg in serum does not appear to be due to analytical limitations of current Tg assays or the presence of TgAb interference.
[METHODS] Fine needle aspiration biopsy (FNAB) washout fluid from patients with DTC LN metastases and undetectable serum Tg measurement by immunoassay (Tg-IA) were evaluated for the presence of Tg and anti-Tg antibodies (TgAbs). Spike-recovery experiments in serum were performed to assess the reason for undetectable Tg.
[RESULTS] Of the 42 patients, 87% had detectable Tg in the FNAB washout fluid by Tg-IA, and 83% by Tg mass spectrometry (Tg-MS) measurement. Seventy-six percent of these patients had detectable serum TgAb, while 26% did not. Tg spike-recovery experiments performed on the TgAb+ (positive) serum samples showed decreased Tg recovery by Tg-IA but not by Tg-MS (Tg-IA mean, range: 50%, 12%-84%; Tg-MS 96%, 70%-117%). In TgAb- (negative) serum samples no interference was observed (>94% recoveries). No difference in FNAB washout fluid Tg recovery between TgAb- and TgAb+ patients was observed.
[CONCLUSION] Tg was detected by both Tg-IA and Tg-MS methods in the majority of FNAB washout fluid from patients with DTC LN metastases who exhibited undetectable serum Tg by Tg-IA and Tg-MS. The absence of serum Tg could not be completely explained by the presence of TgAb. These results suggest that, for a subset of patients with DTC LN metastases, the absence of detectable Tg in serum does not appear to be due to analytical limitations of current Tg assays or the presence of TgAb interference.
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