Higher Distressed Communities Index is associated with more aggressive features in papillary thyroid cancer.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
1062 patients, those from "at risk" (9.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
No associations were found between DCI and tumor mutations or multifocality. [CONCLUSIONS] Patients from "distressed" communities are diagnosed with more advanced thyroid cancer with higher rates of recurrence and death despite no differences in tumor mutational profile.
[BACKGROUND] We sought to identify associations between living in an economically distressed community and the oncologic features and mutational status of papillary thyroid cancer (PTC).
- 95% CI 1.15-3.95
APA
Done JZ, Helbing A, et al. (2025). Higher Distressed Communities Index is associated with more aggressive features in papillary thyroid cancer.. American journal of surgery, 248, 116520. https://doi.org/10.1016/j.amjsurg.2025.116520
MLA
Done JZ, et al.. "Higher Distressed Communities Index is associated with more aggressive features in papillary thyroid cancer.." American journal of surgery, vol. 248, 2025, pp. 116520.
PMID
40684641
Abstract
[BACKGROUND] We sought to identify associations between living in an economically distressed community and the oncologic features and mutational status of papillary thyroid cancer (PTC).
[METHODS] Patients with PTC were identified retrospectively. Community distress was estimated using the Distressed Communities Index (DCI). Logistic regression was used to assess associations between DCI, oncologic features, and tumor mutational status.
[RESULTS] Among 1062 patients, those from "at risk" (9.6%) or "distressed" (7.1%) communities were more likely to have tumors >4 cm (aOR 2.13, 95% CI 1.15-3.95), experience disease recurrence (aOR 1.84, 95% CI 1.16-2.91), and die due to thyroid cancer (aOR 3.56, 95% CI 1.26-10.05) compared to those in "prosperous" (41.6%) communities. No associations were found between DCI and tumor mutations or multifocality.
[CONCLUSIONS] Patients from "distressed" communities are diagnosed with more advanced thyroid cancer with higher rates of recurrence and death despite no differences in tumor mutational profile.
[METHODS] Patients with PTC were identified retrospectively. Community distress was estimated using the Distressed Communities Index (DCI). Logistic regression was used to assess associations between DCI, oncologic features, and tumor mutational status.
[RESULTS] Among 1062 patients, those from "at risk" (9.6%) or "distressed" (7.1%) communities were more likely to have tumors >4 cm (aOR 2.13, 95% CI 1.15-3.95), experience disease recurrence (aOR 1.84, 95% CI 1.16-2.91), and die due to thyroid cancer (aOR 3.56, 95% CI 1.26-10.05) compared to those in "prosperous" (41.6%) communities. No associations were found between DCI and tumor mutations or multifocality.
[CONCLUSIONS] Patients from "distressed" communities are diagnosed with more advanced thyroid cancer with higher rates of recurrence and death despite no differences in tumor mutational profile.
MeSH Terms
Humans; Female; Male; Thyroid Cancer, Papillary; Thyroid Neoplasms; Retrospective Studies; Middle Aged; Adult; Neoplasm Recurrence, Local; Mutation; Aged; Residence Characteristics