Hemithyroidectomy versus total thyroidectomy for patients with differentiated thyroid cancer: a systematic review and meta-analysis.
메타분석
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
238 patients, were analyzed.
I · Intervention 중재 / 시술
total thyroidectomy and 11
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
We found no significant differences between hemithyroidectomy and total thyroidectomy in recurrence rates [RR: 1.
[BACKGROUND] The 2015 American Thyroid Association (ATA) guidelines recommended hemithyroidectomy as an acceptable treatment for patients with differentiated thyroid cancer (DTC) tumors 1-4 cm.
- 표본수 (n) 20,435
- 95% CI 0.985-1.006
- RR 1.036
- 추적기간 8 years
- 연구 설계 systematic review
APA
Hao Q, Segel JE, et al. (2025). Hemithyroidectomy versus total thyroidectomy for patients with differentiated thyroid cancer: a systematic review and meta-analysis.. Gland surgery, 14(11), 2271-2287. https://doi.org/10.21037/gs-2025-364
MLA
Hao Q, et al.. "Hemithyroidectomy versus total thyroidectomy for patients with differentiated thyroid cancer: a systematic review and meta-analysis.." Gland surgery, vol. 14, no. 11, 2025, pp. 2271-2287.
PMID
41377887 ↗
Abstract 한글 요약
[BACKGROUND] The 2015 American Thyroid Association (ATA) guidelines recommended hemithyroidectomy as an acceptable treatment for patients with differentiated thyroid cancer (DTC) tumors 1-4 cm. The primary objectives of this study were to trace the accumulation of evidence supporting hemithyroidectomy prior to the release of the 2015 ATA guidelines and to synthesize the available data on surgical outcomes for hemithyroidectomy and total thyroidectomy.
[METHODS] PubMed was systematically searched for studies comparing hemithyroidectomy and total thyroidectomy among adult patients with DTC ≥1 cm, focusing on patient outcomes including recurrence rates, overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS). Fixed-effects or random-effects models were applied as appropriate to estimate risk ratios (RRs) and hazard ratios (HRs) based on the Woolf test. Cumulative meta-analyses were also performed to illustrate changes in pooled estimates as studies were added incrementally by year of publication.
[RESULTS] The 14 studies, including 176,238 patients, were analyzed. Of these, 88.4% underwent total thyroidectomy and 11.6% (n=20,435) underwent hemithyroidectomy, with a mean follow-up time of 8 years. We found no significant differences between hemithyroidectomy and total thyroidectomy in recurrence rates [RR: 1.036, 95% confidence interval (CI): 0.698-1.538], OS (RR: 0.995; 95% CI: 0.985-1.006), or DSS (RR: 1.001; 95% CI: 0.998-1.005). Total thyroidectomy was associated with marginally better DFS compared to hemithyroidectomy (RR: 0.980, 95% CI: 0.963-0.997).
[CONCLUSIONS] This systematic review and meta-analysis found that total thyroidectomy was associated with slightly greater DFS relative to hemithyroidectomy, but no statistically significant differences were observed in recurrence, OS, and DSS between the two procedures. The accumulation of evidence supporting hemithyroidectomy may have prompted the ATA to revise their guidelines and encouraged surgeons to increasingly consider hemithyroidectomy as a safe procedure for treating patients with DTC ≥1 cm.
[METHODS] PubMed was systematically searched for studies comparing hemithyroidectomy and total thyroidectomy among adult patients with DTC ≥1 cm, focusing on patient outcomes including recurrence rates, overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS). Fixed-effects or random-effects models were applied as appropriate to estimate risk ratios (RRs) and hazard ratios (HRs) based on the Woolf test. Cumulative meta-analyses were also performed to illustrate changes in pooled estimates as studies were added incrementally by year of publication.
[RESULTS] The 14 studies, including 176,238 patients, were analyzed. Of these, 88.4% underwent total thyroidectomy and 11.6% (n=20,435) underwent hemithyroidectomy, with a mean follow-up time of 8 years. We found no significant differences between hemithyroidectomy and total thyroidectomy in recurrence rates [RR: 1.036, 95% confidence interval (CI): 0.698-1.538], OS (RR: 0.995; 95% CI: 0.985-1.006), or DSS (RR: 1.001; 95% CI: 0.998-1.005). Total thyroidectomy was associated with marginally better DFS compared to hemithyroidectomy (RR: 0.980, 95% CI: 0.963-0.997).
[CONCLUSIONS] This systematic review and meta-analysis found that total thyroidectomy was associated with slightly greater DFS relative to hemithyroidectomy, but no statistically significant differences were observed in recurrence, OS, and DSS between the two procedures. The accumulation of evidence supporting hemithyroidectomy may have prompted the ATA to revise their guidelines and encouraged surgeons to increasingly consider hemithyroidectomy as a safe procedure for treating patients with DTC ≥1 cm.
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