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[F]AlF-NOTA-FAPI-04 PET/CT improves detection of subcentimeter recurrent lesions in differentiated thyroid cancer.

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European journal of nuclear medicine and molecular imaging 2025 Vol.53(1) p. 398-407
Retraction 확인
출처
PubMed DOI PMC

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문
P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
[F]AlF-NOTA-FAPI-04 PET/CT, including 16 who underwent paired [F]FDG scans
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Notably, 7 cervical lymph node metastases (mean diameter 5.9 ± 1.4 mm) were detected exclusively by FAPI imaging. [CONCLUSION] [F]AlF-NOTA-FAPI-04 PET/CT exhibits superior diagnostic performance over [F]FDG PET/CT in detecting small metastatic lesions in recurrent DTC, potentially enabling earlier intervention and improved patient management.

Zheng K, Zhou W, Yang J, Zhang Y, Jiang C, Xie A, Peng X, Dai J, He H, Peng X, Ye H

PMC 전문 ↗ 원문 ↗ DOI ↗ BibTeX ↓ RIS ↓
📝 환자 설명용 한 줄

[PURPOSE] Fibroblast activation protein (FAP)-targeted PET/CT has emerged as a promising tool for visualizing tumor stroma.

🔬 핵심 임상 통계 (초록에서 자동 추출 — 원문 검증 권장)
  • p-value P = 0.002
  • p-value P < 0.001
  • Sensitivity 75%

이 논문을 인용하기

BibTeX ↓ RIS ↓
APA Zheng K, Zhou W, et al. (2025). [F]AlF-NOTA-FAPI-04 PET/CT improves detection of subcentimeter recurrent lesions in differentiated thyroid cancer.. European journal of nuclear medicine and molecular imaging, 53(1), 398-407. https://doi.org/10.1007/s00259-025-07433-6
MLA Zheng K, et al.. "[F]AlF-NOTA-FAPI-04 PET/CT improves detection of subcentimeter recurrent lesions in differentiated thyroid cancer.." European journal of nuclear medicine and molecular imaging, vol. 53, no. 1, 2025, pp. 398-407.
PMID 40663160
DOI 10.1007/s00259-025-07433-6

Abstract

[PURPOSE] Fibroblast activation protein (FAP)-targeted PET/CT has emerged as a promising tool for visualizing tumor stroma. This study aimed to validate the diagnostic efficacy of [F]AlF-NOTA-FAPI-04 PET/CT in detecting subclinical metastases in recurrent differentiated thyroid cancer (DTC), with direct comparison to [F]FDG PET/CT.

[METHODS] Twenty-three DTC participants with biochemical recurrence (suppressed thyroglobulin [Tg] ≥ 1 ng/mL or Tg antibodies [Tg-Ab] > 115 IU/mL) underwent [F]AlF-NOTA-FAPI-04 PET/CT, including 16 who underwent paired [F]FDG scans. Lesion classification followed histopathology or 15.5-month clinical follow-up (median, 8-32 months).

[RESULTS] [F]AlF-NOTA-FAPI-04 PET/CT demonstrated significantly higher lesion-level sensitivity (75% vs. 13%, P = 0.002) and accuracy (80% vs. 27%, P < 0.001) than [F]FDG. Participant-level sensitivity reached 100% (7/7 vs. 14% [1/7], P = 0.003). Notably, 7 cervical lymph node metastases (mean diameter 5.9 ± 1.4 mm) were detected exclusively by FAPI imaging.

[CONCLUSION] [F]AlF-NOTA-FAPI-04 PET/CT exhibits superior diagnostic performance over [F]FDG PET/CT in detecting small metastatic lesions in recurrent DTC, potentially enabling earlier intervention and improved patient management.

MeSH Terms

Humans; Thyroid Neoplasms; Positron Emission Tomography Computed Tomography; Female; Male; Middle Aged; Adult; Aged; Recurrence; Fluorodeoxyglucose F18; Neoplasm Recurrence, Local

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