Stable Iodine Intake and Thyroid Screening Outcomes After the Fukushima Nuclear Disaster: An Observational Study.

[CONTEXT] Stable iodine intake is crucial in preventing thyroid cancer after radiological emergencies; however, the association between stable iodine intake and thyroid outcomes in children after the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident remains unclear.

[OBJECTIVE] To describe thyroid screening outcomes and investigate the association between stable iodine intake and those outcomes in children after the FDNPP accident.

[METHODS] This was an observational study based on data from the regional thyroid screening program conducted by the Research Institute of Radiation Safety for Disaster Recovery Support in Fukushima, Japan. Participants were children born between April 1998 and March 2011 in Miharu Town (n = 1974), where stable iodine intake was implemented during the FDNPP accident. The association between stable iodine intake and thyroid ultrasound results was examined using logistic regression analysis. Coarsened exact matching was used to balance sex and age.

[RESULTS] Among the participants, 1095 (55.5%) consumed stable iodine, whereas 879 (44.5%) did not. In the age- and sex-matched group of 1952 children (1088 in the intake and 864 in non-intake group), no association was observed between stable iodine intake and thyroid screening results indicating the need for a detailed examination (odds ratio: 0.839; 95% CI: 0.393-1.8, P = .647). The volume and parenchymal heterogeneity were not different between these groups.

[CONCLUSION] Stable iodine intake was not associated with thyroid ultrasound screening results, probably because of the low radiation doses following the FDNPP accident. Parenchymal heterogeneity and thyroid volume were similar, supporting the conclusion that the adverse effects of single-dose stable iodine are minimal.