Effect of early multiple acid stimulation on salivary gland Tc-99m pertechnetate uptake: a prospective study.
1/5 보강
[INTRODUCTION] Salivary gland dysfunction is a common side effect of radioiodine-131 (ˆ131I) therapy for differentiated thyroid cancer (DTC).
- p-value P < 0.001
APA
Zhu H, Shen W, et al. (2026). Effect of early multiple acid stimulation on salivary gland Tc-99m pertechnetate uptake: a prospective study.. Radiography (London, England : 1995), 32(1), 103217. https://doi.org/10.1016/j.radi.2025.103217
MLA
Zhu H, et al.. "Effect of early multiple acid stimulation on salivary gland Tc-99m pertechnetate uptake: a prospective study.." Radiography (London, England : 1995), vol. 32, no. 1, 2026, pp. 103217.
PMID
41172765 ↗
Abstract 한글 요약
[INTRODUCTION] Salivary gland dysfunction is a common side effect of radioiodine-131 (ˆ131I) therapy for differentiated thyroid cancer (DTC). We hypothesized that early repeated acid stimulation during Tc-99m salivary gland scintigraphy would reduce radioactive tracer accumulation in salivary glands.
[METHODS] Eighty-one post-thyroidectomy patients with DTC were assigned to three equal groups: control (no acid stimulation), single stimulation at 2 h post-injection, and early repeated stimulation every 30 min after Tc-99m Pertechnetate (TcO) injection. TcO salivary gland scintigraphy was performed with regions of interest delineated for bilateral parotid and submandibular glands. Time-activity curves were generated over 2.5 h, and radioactivity counts and accumulation ratios were calculated at defined intervals.
[RESULTS] Baseline parotid and submandibular radioactivity counts did not differ significantly across groups (parotid: P > 0.05; submandibular: P > 0.05). Both acid stimulation protocols induced significant reductions in glandular radioactivity compared with control at all dynamic acquisition intervals (P < 0.001). Cumulative tracer accumulation was significantly lower in the early repeated stimulation group versus the control and single-stimulation groups (P < 0.001). At the same time, no significant difference was observed between control and single-stimulation groups.
[CONCLUSION] Early repeated acid stimulation markedly decreases TcO uptake and retention in salivary glands, outperforming delayed single stimulation.
[IMPLICATIONS FOR PRACTICE] Implementing early repeated acid stimulation during 131I therapy may help prevent salivary gland injury and preserve gland function in DTC patients.
[METHODS] Eighty-one post-thyroidectomy patients with DTC were assigned to three equal groups: control (no acid stimulation), single stimulation at 2 h post-injection, and early repeated stimulation every 30 min after Tc-99m Pertechnetate (TcO) injection. TcO salivary gland scintigraphy was performed with regions of interest delineated for bilateral parotid and submandibular glands. Time-activity curves were generated over 2.5 h, and radioactivity counts and accumulation ratios were calculated at defined intervals.
[RESULTS] Baseline parotid and submandibular radioactivity counts did not differ significantly across groups (parotid: P > 0.05; submandibular: P > 0.05). Both acid stimulation protocols induced significant reductions in glandular radioactivity compared with control at all dynamic acquisition intervals (P < 0.001). Cumulative tracer accumulation was significantly lower in the early repeated stimulation group versus the control and single-stimulation groups (P < 0.001). At the same time, no significant difference was observed between control and single-stimulation groups.
[CONCLUSION] Early repeated acid stimulation markedly decreases TcO uptake and retention in salivary glands, outperforming delayed single stimulation.
[IMPLICATIONS FOR PRACTICE] Implementing early repeated acid stimulation during 131I therapy may help prevent salivary gland injury and preserve gland function in DTC patients.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Sodium Pertechnetate Tc 99m
- Male
- Female
- Prospective Studies
- Middle Aged
- Adult
- Salivary Glands
- Radiopharmaceuticals
- Thyroid Neoplasms
- Radionuclide Imaging
- Iodine Radioisotopes
- Thyroidectomy
- Aged
- 99mTc-pertechnetate ((99m)TcO(4)(-))
- Differentiated thyroid cancer (DTC)
- Early repeated acid stimulation
- Salivary gland scintigraphy
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