Deceptive Thyroid Pathologies: Anaplastic Thyroid Carcinoma Mimics and Clinical Implications.
증례연속
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: unusual malignancies that mimic similar aggressive cancers
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Two patients had mucoepidermoid carcinoma (MEC) variants-one classic MEC and one sclerosing MEC with eosinophilia (SMECE). [CONCLUSIONS] Multiple rare thyroid malignancies may present indistinguishably from ATC, emphasizing the need for meticulous histopathologic and molecular evaluation.
[BACKGROUND] Beyond follicular-derived thyroid carcinomas, lymphomas, and metastatic disease, there are rare pathologies of the thyroid gland that represent a challenge.
APA
Allen DZ, Hosseini SM, et al. (2026). Deceptive Thyroid Pathologies: Anaplastic Thyroid Carcinoma Mimics and Clinical Implications.. Head & neck. https://doi.org/10.1002/hed.70201
MLA
Allen DZ, et al.. "Deceptive Thyroid Pathologies: Anaplastic Thyroid Carcinoma Mimics and Clinical Implications.." Head & neck, 2026.
PMID
41834435
Abstract
[BACKGROUND] Beyond follicular-derived thyroid carcinomas, lymphomas, and metastatic disease, there are rare pathologies of the thyroid gland that represent a challenge. We report patients with unusual malignancies that mimic similar aggressive cancers.
[METHODS] Retrospective case series.
[RESULTS] Eight patients with aggressive thyroid tumors presented with clinical and radiographic features concerning for anaplastic thyroid cancer (ATC). Three patients presumed to be diagnosed with Adamantinoma-like Ewing sarcoma (ALES), each harboring an EWSR1-FLI1 rearrangement. One patient with an enlarging neck mass was found to have osteoid-producing osteosarcoma. Another patient with a bulky neck mass and metastases demonstrated neolumen and ERG/CD31 positivity, confirming thyroid angiosarcoma. A separate patient was diagnosed with a high-grade sarcoma harboring a PRMT8-NTRK fusion, representing the first reported case. Two patients had mucoepidermoid carcinoma (MEC) variants-one classic MEC and one sclerosing MEC with eosinophilia (SMECE).
[CONCLUSIONS] Multiple rare thyroid malignancies may present indistinguishably from ATC, emphasizing the need for meticulous histopathologic and molecular evaluation.
[METHODS] Retrospective case series.
[RESULTS] Eight patients with aggressive thyroid tumors presented with clinical and radiographic features concerning for anaplastic thyroid cancer (ATC). Three patients presumed to be diagnosed with Adamantinoma-like Ewing sarcoma (ALES), each harboring an EWSR1-FLI1 rearrangement. One patient with an enlarging neck mass was found to have osteoid-producing osteosarcoma. Another patient with a bulky neck mass and metastases demonstrated neolumen and ERG/CD31 positivity, confirming thyroid angiosarcoma. A separate patient was diagnosed with a high-grade sarcoma harboring a PRMT8-NTRK fusion, representing the first reported case. Two patients had mucoepidermoid carcinoma (MEC) variants-one classic MEC and one sclerosing MEC with eosinophilia (SMECE).
[CONCLUSIONS] Multiple rare thyroid malignancies may present indistinguishably from ATC, emphasizing the need for meticulous histopathologic and molecular evaluation.