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Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma.

The Laryngoscope 2026

Gohari SS, Wasserman I, Philteos J, Richmon JD

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Markedly elevated thyroglobulin (Tg) washout is often considered highly suggestive of metastatic differentiated thyroid cancer.

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BibTeX ↓ RIS ↓
APA Gohari SS, Wasserman I, et al. (2026). Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma.. The Laryngoscope. https://doi.org/10.1002/lary.70556
MLA Gohari SS, et al.. "Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma.." The Laryngoscope, 2026.
PMID 41943071
DOI 10.1002/lary.70556

Abstract

Markedly elevated thyroglobulin (Tg) washout is often considered highly suggestive of metastatic differentiated thyroid cancer. We present two cases of false-positive Tg washout in cervical lymph nodes with benign pathology, notably in patients who were carriers of iron-handling disorders. These findings highlight the limitations of Tg washout as a standalone marker and the need for multimodal interpretation.