Prognostic value of lncRNA HCG4 in thyroid cancer and its regulatory effect on tumor progression.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
128 patients with PTC.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] HCG4 demonstrates favorable prognostic value. Overexpression of HCG4 can reduce the level of miR-146b-5p, inhibit the survival rate and invasiveness of PTC cells, and thereby potentially alleviate the progression of PTC.
[INTRODUCTION] Papillary thyroid carcinoma (PTC) with metastasis has a poor prognosis and requires effective prognostic markers.
APA
Qian C, Yi H, Wang J (2026). Prognostic value of lncRNA HCG4 in thyroid cancer and its regulatory effect on tumor progression.. Endokrynologia Polska. https://doi.org/10.5603/ep.109546
MLA
Qian C, et al.. "Prognostic value of lncRNA HCG4 in thyroid cancer and its regulatory effect on tumor progression.." Endokrynologia Polska, 2026.
PMID
41954581
Abstract
[INTRODUCTION] Papillary thyroid carcinoma (PTC) with metastasis has a poor prognosis and requires effective prognostic markers. Becauselong non-coding ribonucleic acid (lncRNA) HCG4 is abnormally expressed in thyroid cancer, this study investigated its prognostic valuefor PTC and its regulatory mechanisms.
[MATERIAL AND METHODS] This study included 128 patients with PTC. The prognostic value of HCG4 was assessed using Kaplan-Meier curves.COX analysis was used to identify prognostic factors affecting PTC. HCG4 and miR-146b-5p levels in tissues and cells were assessed usingreal-time quantitative reverse transcription polymerase chain reaction (RT-qPCR). Cell proliferation was detected using a cell counting kit(CCK-8 kit). Cell invasion and migration were assessed using a Transwell assay. The binding relationship between HCG4 and miR-146b-5pwas detected using dual-luciferase reporter (DLR).
[RESULTS] HCG4 levels were reduced in PTC tissues, and cells compared with normal tissues, while miR-146b-5p levels were increased. PTCpatients with low HCG4 levels demonstrated lower 5-year survival rates, and HCG4 also serves as an independent protective prognosticfactor for PTC. HCG4 negatively regulates the level of miR-146b-5p. HCG4 overexpression inhibits cell proliferation, invasion, and migrationabilities of the cells. These abilities were restored by increasing the level of miR-146b-5p. Therefore, increasing HCG4 could reducethe level of miR-146b-5p, thereby alleviating PTC development.
[CONCLUSIONS] HCG4 demonstrates favorable prognostic value. Overexpression of HCG4 can reduce the level of miR-146b-5p, inhibit the survival rate and invasiveness of PTC cells, and thereby potentially alleviate the progression of PTC.
[MATERIAL AND METHODS] This study included 128 patients with PTC. The prognostic value of HCG4 was assessed using Kaplan-Meier curves.COX analysis was used to identify prognostic factors affecting PTC. HCG4 and miR-146b-5p levels in tissues and cells were assessed usingreal-time quantitative reverse transcription polymerase chain reaction (RT-qPCR). Cell proliferation was detected using a cell counting kit(CCK-8 kit). Cell invasion and migration were assessed using a Transwell assay. The binding relationship between HCG4 and miR-146b-5pwas detected using dual-luciferase reporter (DLR).
[RESULTS] HCG4 levels were reduced in PTC tissues, and cells compared with normal tissues, while miR-146b-5p levels were increased. PTCpatients with low HCG4 levels demonstrated lower 5-year survival rates, and HCG4 also serves as an independent protective prognosticfactor for PTC. HCG4 negatively regulates the level of miR-146b-5p. HCG4 overexpression inhibits cell proliferation, invasion, and migrationabilities of the cells. These abilities were restored by increasing the level of miR-146b-5p. Therefore, increasing HCG4 could reducethe level of miR-146b-5p, thereby alleviating PTC development.
[CONCLUSIONS] HCG4 demonstrates favorable prognostic value. Overexpression of HCG4 can reduce the level of miR-146b-5p, inhibit the survival rate and invasiveness of PTC cells, and thereby potentially alleviate the progression of PTC.