Cellular Proliferation Imaging With 18 F-FMAU PET/CT as Adjunct to mpMRI in Image-Guided Biopsy of Suspected Prostate Cancer.
[PURPOSE] We evaluated the potential diagnostic utility of PET with the cellular proliferation biomarker, 2'-deoxyl-2'-[ 18 F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ( 18 F-FMAU), as an adjunc
APA
Jadvar H, Chen K, et al. (2025). Cellular Proliferation Imaging With 18 F-FMAU PET/CT as Adjunct to mpMRI in Image-Guided Biopsy of Suspected Prostate Cancer.. Clinical nuclear medicine, 50(6), e340-e343. https://doi.org/10.1097/RLU.0000000000005702
MLA
Jadvar H, et al.. "Cellular Proliferation Imaging With 18 F-FMAU PET/CT as Adjunct to mpMRI in Image-Guided Biopsy of Suspected Prostate Cancer.." Clinical nuclear medicine, vol. 50, no. 6, 2025, pp. e340-e343.
PMID
39924745
Abstract
[PURPOSE] We evaluated the potential diagnostic utility of PET with the cellular proliferation biomarker, 2'-deoxyl-2'-[ 18 F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ( 18 F-FMAU), as an adjunct to multiparametric MRI (mpMRI), in localization of sites for image-guided biopsy in men with suspected prostate cancer.
[PATIENTS AND MATERIALS] Seventeen men with clinically suspected prostate cancer underwent standard mpMRI and investigational PET/CT with 18 F-FMAU.
[RESULTS] Tissue samples obtained from 22 image-guided biopsies were examined histologically. There were 11 benign, 6 ISUP grade 1, and 5 ISUP grade 2 tumors. The sensitivity for detection of ISUP 1 and ISUP 2 prostate cancer was 16.7% and 100% for mpMRI, and 50% and 60% for 18 F-FMAU PET/CT, respectively.
[CONCLUSIONS] 18 F-FMAU PET/CT may be a useful adjunct to mpMRI in image-guided prostate biopsy.
[PATIENTS AND MATERIALS] Seventeen men with clinically suspected prostate cancer underwent standard mpMRI and investigational PET/CT with 18 F-FMAU.
[RESULTS] Tissue samples obtained from 22 image-guided biopsies were examined histologically. There were 11 benign, 6 ISUP grade 1, and 5 ISUP grade 2 tumors. The sensitivity for detection of ISUP 1 and ISUP 2 prostate cancer was 16.7% and 100% for mpMRI, and 50% and 60% for 18 F-FMAU PET/CT, respectively.
[CONCLUSIONS] 18 F-FMAU PET/CT may be a useful adjunct to mpMRI in image-guided prostate biopsy.
MeSH Terms
Humans; Male; Prostatic Neoplasms; Positron Emission Tomography Computed Tomography; Image-Guided Biopsy; Aged; Multiparametric Magnetic Resonance Imaging; Middle Aged; Cell Proliferation; Arabinofuranosyluracil