Liposarcoma of the Spermatic Cord: A Rare Case Following a Decade of Radiotherapy for Prostate Cancer.

Liposarcoma of the spermatic cord is an uncommon malignant tumor, and even rarer in the setting of prior radiotherapy for prostate cancer. It often presents as a painless inguinal or scrotal mass and is frequently mistaken for more common conditions like inguinal hernia or hydrocele. We report a case of a 75-year-old man with a history of prostate cancer treated with radiotherapy a decade ago, who presented with a painless swelling in his left groin. Initial imaging suggested an inguinal hernia, but histopathological examination revealed a poorly differentiated, high-grade liposarcoma of the spermatic cord with lymphovascular invasion and periosteal involvement. Treatment included radical orchiectomy and broad tumor excision, followed by radiation therapy. Despite this, the patient experienced a recurrence, necessitating further interventions, including coil embolization and systemic therapy. This case highlights the potential association between radiotherapy for prostate cancer and the subsequent development of secondary malignancies such as liposarcoma of the spermatic cord.