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Interactions between phytotherapeutics and chemotherapeutics: the current evidence.

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Expert opinion on drug metabolism & toxicology 2025 Vol.21(7) p. 831-845
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Allegra S, Chiara F, Abbadessa G, Di Pietro A, Caudana M, De Francia S

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[INTRODUCTION] The historical context of phytotherapy affects its potential as therapeutic products, and bioactive metabolites are crucial to the pharmacological effects, safety and effectiveness of a

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APA Allegra S, Chiara F, et al. (2025). Interactions between phytotherapeutics and chemotherapeutics: the current evidence.. Expert opinion on drug metabolism & toxicology, 21(7), 831-845. https://doi.org/10.1080/17425255.2025.2517733
MLA Allegra S, et al.. "Interactions between phytotherapeutics and chemotherapeutics: the current evidence.." Expert opinion on drug metabolism & toxicology, vol. 21, no. 7, 2025, pp. 831-845.
PMID 40491352 ↗

Abstract

[INTRODUCTION] The historical context of phytotherapy affects its potential as therapeutic products, and bioactive metabolites are crucial to the pharmacological effects, safety and effectiveness of alternative medicines.

[AREAS COVERED] Phytotherapy is of great interest to cancer patients. Therefore, the purpose of this study was to gather publications about the interactions between chemotherapy and phytotherapeutics, medicinal plants, and similar formulations. To find publications published between January 2015 and January 2025, a MEDLINE PubMed search was conducted.

[EXPERT OPINION] Several scientists and medical specialists have been looking into the potential of natural items to heal microbial cancer and chemotherapy-related adverse effects. The main factor influencing phytochemicals anticancer effectiveness is their ability to target a variety of pathways, including antimutagenic, antioxidant, and antiproliferative qualities. They can also regulate the host immune response to cancer by improving the surveillance of lymphocytes in cancer cells and lowering the inflammatory milieu. Because carcinogenesis is complex and involves a wide range of factors and signaling cascades, phytochemicals that target several targets may be useful anticancer drugs.

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