Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer.
1/5 보강
Squamous transformation of prostate adenocarcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment.
APA
Semaan K, Nawfal R, et al. (2025). Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer.. NPJ precision oncology, 9(1), 233. https://doi.org/10.1038/s41698-025-01031-3
MLA
Semaan K, et al.. "Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer.." NPJ precision oncology, vol. 9, no. 1, 2025, pp. 233.
PMID
40634667 ↗
Abstract 한글 요약
Squamous transformation of prostate adenocarcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment. Herein, we profile circulating chromatin in serial plasma samples collected from a patient with metastatic prostate cancer that experienced squamous transformation. We detect dynamic changes in gene regulation from circulating chromatin reflecting the emergence of squamous differentiation, enabling non-invasive diagnosis and monitoring of this resistance phenotype, with potential therapeutic implications.